System-of-Systems Navigator: An Approach for Managing System-of-Systems Interoperability [PDF]
We have crossed a threshold where most of our large software systems can no longer be constructed as monoliths specified by a single, focused, and unified team; implemented as a unit; and tested to be within known performance limits. They are now constructed as groups of interoperating systems (as systems of systems) developed by different but ...
James Smith Ii+4 more
openaire +2 more sources
Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions
Diet-induced metabolic endotoxemia is an important factor in the development of many chronic diseases in animals and man. The gut epithelium is an efficient barrier that prevents the absorption of liposaccharide (LPS).
S. Mohammad, C. Thiemermann
semanticscholar +1 more source
The multi-layer network nature of systemic risk and its implications for the costs of financial crises [PDF]
The inability to see and quantify systemic financial risk comes at an immense social cost. Systemic risk in the financial system arises to a large extent as a consequence of the interconnectedness of its institutions, which are linked through networks of
Martínez-Jaramillo, Serafín+4 more
core +2 more sources
Systemic inflammation markers and cancer incidence in the UK Biobank
Systemic inflammation markers have been linked to increased cancer risk and mortality in a number of studies. However, few studies have estimated pre-diagnostic associations of systemic inflammation markers and cancer risk.
T. Nøst+6 more
semanticscholar +1 more source
Síndrome stiff skin: relato de caso Stiff skin syndrome: case report
Síndrome stiff skin é doença rara, esclerodermiforme, de etiologia desconhecida, caracterizada por endurecimento pétreo da pele, hipertricose leve e limitação da mobilidade articular. Não há tratamento efetivo até o momento. Exercícios e reabilitação são
Adriana Gutstein da Fonseca Amorim+3 more
doaj +1 more source
In systemic sclerosis skin perfusion of hands is reduced and may predict the occurrence of new digital ulcers [PDF]
Systemic sclerosis (SSc) patients are at high risk for the development of ischemic digital ulcers (DUs). The aim of this study was to assess in SSc patients a correlation between skin perfusion evaluated by LDPI and DUs and to evaluate the prognostic ...
Barbano, Biagio+6 more
core +1 more source
Macroprudential policy and bank systemic risk [PDF]
This paper investigates the effectiveness of macroprudential policy to contain the systemicrisk of European banks between 2000 and 2017. We use a new database (MaPPED) collected by experts at the ECB and national central banks with narrative ...
Meuleman, Elien, Vander Vennet, Rudi
core +1 more source
2019 update of the EULAR recommendations for the management of systemic lupus erythematosus
Our objective was to update the EULAR recommendations for the management of systemic lupus erythematosus (SLE), based on emerging new evidence. We performed a systematic literature review (01/2007–12/2017), followed by modified Delphi method, to form ...
A. Fanouriakis+27 more
semanticscholar +1 more source
Sjögren’s syndrome: a systemic autoimmune disease
Sjögren’s syndrome is a chronic autoimmune disease characterized by ocular and oral dryness resulting from lacrimal and salivary gland dysfunction. Besides, a variety of systemic manifestations may occur, involving virtually any organ system. As a result,
S. Negrini+7 more
semanticscholar +1 more source
What is the Minimal Systemic Risk in Financial Exposure Networks? [PDF]
Management of systemic risk in financial markets is traditionally associated with setting (higher) capital requirements for market participants. There are indications that while equity ratios have been increased massively since the financial crisis ...
Diem, Christian+2 more
core +2 more sources