Results 51 to 60 of about 197,355 (287)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Broad-Spectrum Acquired Resistance in Barley Induced by the Pseudomonas Pathosystem Shares Transcriptional Components with Arabidopsis Systemic Acquired Resistance

Molecular Plant-Microbe Interactions, 2012
Inducible resistance responses play a central role in the defense of plants against pathogen attack. Acquired resistance (AR) is induced alongside defense toward primary attack, providing broad-spectrum protection against subsequent pathogen challenge ...
E. H. Colebrook, G. Creissen, G. R. D. McGrann, R. Dreos, C. Lamb, L. A. Boyd   +5 more
doaj   +1 more source

Bacterial elicitors of the plant immune system: An overview and the way forward

Plant Stress, 2023
A wide variety of root-associated bacterial mutualist species sensitize plant defenses to counteract pathogen infections. These beneficial bacteria produce myriad molecules that induce systemic resistance (ISR) in plants.
Ma. del Carmen Orozco-Mosqueda, Ayomide Emmanuel Fadiji, Olubukola Oluranti Babalola, Gustavo Santoyo   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A newly identified glycosyltransferase AsRCOM provides resistance to purple curl leaf disease in agave

BMC Genomics, 2023
Background Purple curl leaf disease brings a significant threat to the development of agave industry, the underlying mechanism of disease-resistant Agave sisalana. hybrid 11648 (A. H11648R) is still unknown.
Zhiwei Lu, Xiaowan Hou, Zhi Ke, Yanmei Zhang, ZiPing Yang, Wenzhao Zhou   +5 more
doaj   +1 more source

Plant Disease Management: Leveraging on the Plant-Microbe-Soil Interface in the Biorational Use of Organic Amendments

Frontiers in Plant Science, 2021
Agriculture is faced with many challenges including loss of biodiversity, chemical contamination of soils, and plant pests and diseases, all of which can directly compromise plant productivity and health.
Akinlolu Olalekan Akanmu, Olubukola Oluranti Babalola, Vittorio Venturi, Modupe Stella Ayilara, Bartholomew Saanu Adeleke, Adenike Eunice Amoo, Ayodele Adegboyega Sobowale, Ayomide Emmanuel Fadiji, Bernard R. Glick   +8 more
doaj   +1 more source

Antiviral and quality effects of chemical elictors and Cucumber Mosaic Virus (CMV) infection on tomato plants and fruits [PDF]

, 2012
Cucumber mosaic virus (CMV) has emerged as one of the most serious threats to tomato cultivation in Greece. In the present study the effects of Benzothiadiazoles (BTH) and pyraclostrobin against mechanically or aphid-transmitted CMV in tomato plants ...
Kalogirou, Maria
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

miR-200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression. [PDF]

, 2012
Acquired resistance to classical chemotherapeutics is a major obstacle in cancer treatment. Doxorubicin is frequently used in breast cancer therapy either as single-agent or in combination with other drugs like docetaxel and cyclophosphamide.
Oak, Prajakta S., Prajakta S. Oak (115995), Florian Kopp, Andreas Roidl, Kopp, Florian, Roidl, Andreas, Prajakta S Oak, Florian Kopp (115988), Ernst Wagner (60760), Andreas Roidl (116002), Wagner, Ernst, Ernst Wagner   +11 more
core   +1 more source