Results 61 to 70 of about 12,519,817 (288)
Pharmacogenomics: a systems approach [PDF]
WIREs Systems Biology and Medicine, 2010 AbstractPharmacogenetics and pharmacogenomics involve the study of the role of inheritance in individual variation in drug response, a phenotype that varies from potentially life‐threatening adverse drug reactions to equally serious lack of therapeutic efficacy.
openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Soviet Aesthetics of the 1960s in Defense of Humanitarian Values [PDF]
Художественная культураThe article analyses the main directions of theoretical and methodological inquiry pursued by Soviet aestheticians in the 1960s and assesses their contribution to the development of domestic aesthetics.
Ustyugova Elena N.
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Systemic model of intelligent organization [PDF]
مدیریت راهبردی دانش سازمانیPurpose: This research aims to design a "Systematic Model of a Smart Organization" employing a systemic approach, thereby providing an operational framework for organizations to transition from traditional structures to adaptable ecosystems in the era of
Gholamreza Salmanpoor Siavoshi +1 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Hormonal regulation of mammal glands and premenstrual syndrome
Лечащий Врач, 2021 The problem of premenstrual syndrome was considered, as well as the reasons of its development, clinical signs and forms, aswell as the possibilities of symptomatic treatment and prevention.
Ch. N. Mustafin
doaj
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Designing hypercitizenship methodologically
Revista de Direito Econômico e Socioambiental, 2014 This paper is essentially epistemological and methodological and is aimed at designing the hypercitizen methodological toolkit. It is not merely through an indicator based approach but also on a modelling based approach and a metatheoretical one ...
Andrea Pitasi
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