Results 81 to 90 of about 2,052,932 (306)
Security Management - Systems Approach [PDF]
Acta Informatica Pragensia, 2015 The aim of the contribution is the use of the systems approach to treat security management as a practical field and new scientific discipline. The philosophy of systems approach to the solution of problems generally is an adequate methodological basis even for the theory of management. The path to the real optimization of security situation leads only
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Hormonal regulation of mammal glands and premenstrual syndrome
Лечащий Врач, 2021 The problem of premenstrual syndrome was considered, as well as the reasons of its development, clinical signs and forms, aswell as the possibilities of symptomatic treatment and prevention.
Ch. N. Mustafin
doaj
Soviet Aesthetics of the 1960s in Defense of Humanitarian Values [PDF]
Художественная культураThe article analyses the main directions of theoretical and methodological inquiry pursued by Soviet aestheticians in the 1960s and assesses their contribution to the development of domestic aesthetics.
Ustyugova Elena N.
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
A Systemic Approach to Money Demand Modeling [PDF]
This paper uses a consumer theory-based systemic approach to model the demand for monetary liquid asset holdings. We implement the suggestions and caveats of aggregation theory for the estimation of a demand system for liquid assets (monies) in static ...
J. Rodrigo Fuentes +2 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Exceptional and Durable Responses to TDM-1 After Trastuzumab Failure for Breast Cancer Skin Metastases: Potential Implications of an Immunological Sanctuary [PDF]
, 2018 Breast Cancer (BC) skin metastases represent a challenging clinical scenario. Although they usually arise when other distant metastases are already present, they may also represent a form of locoregional recurrence (LRR). Systemic therapy in this setting
Dieci, Maria V +8 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Supporting Water Governance and Climate Change Adaptation Through Systemic Praxis [PDF]
, 2013 Understanding and working with multiple perspectives on issues of change is an essential part of managing “common pool” water resources. In uncertain and complex situations arising from changes in human settlements and climate, both lives and livelihoods
Blackmore, Chris +2 more
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