Results 71 to 80 of about 2,052,932 (306)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
An examination of bank risk measures and their relationship to systemic risk measurement : a dissertation presented in partial fulfilment of the requirements for the degree of Doctoral of Philosophy in Finance at Massey University, Manawatu (Turitea), New Zealand [PDF]
, 2018 This research explores ways of measuring bank risk, both individual bank risk and systemic risk, with the main focus on z-score. Z-score is a popular indicator of individual bank risk-taking.
Li, Xiping
core
On environments as systemic exoskeletons: Crosscutting optimizers and antifragility enablers
, 2015 Classic approaches to General Systems Theory often adopt an individual perspective and a limited number of systemic classes. As a result, those classes include a wide number and variety of systems that result equivalent to each other.
De Florio, Vincenzo
core +1 more source
Towards a socio-historical analysis of Ancient Greek? Some problems and prospects [PDF]
, 2017 Recent findings in sociolinguistics have greatly enhanced our understanding of the mechanisms of linguistic variation and change. In this paper, I discuss the possibility of applying a historical sociolinguistic approach to a corpus language such as ...
Bentein, Klaas
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Model of formation of tutoring competence of future educational psychologists
Вестник Самарского университета: История, педагогика, филологияThe article discusses the problem of individualization of training and substantiates the importance of developing a specialist’s tutoring competence. When designing a model for the formation of tutoring competence of future educational psychologists, the
A. N. Rylov, N. V. Solovova
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Gestão & Produção, 2001 A palavra qualidade tem sido nos últimos anos sinônimo de sucesso ou fracasso em muitas empresas, sendo que esta situação resulta de como estas empresas compreendem os conceitos de qualidade.
Felipe Araújo Calarge +1 more
doaj +1 more source