Results 91 to 100 of about 2,052,932 (306)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Modelling Nonlinear Preloaded Multi-Bolted Systems on the Operational State

Engineering Transactions, 2016
Modelling and calculations of asymmetrical multi-bolted connections at the operational stage are presented. The physical model of the joint is based on a flexible flange element that is connected with a flexible support by means of the rigid body bolt ...
Rafał GRZEJDA
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Editorial: Inflammation in Obesity: From Physiological to Pathological Aspects

Frontiers in Nutrition, 2022
Marina C. Oliveira, Geneviève Marcelin, Emmanuel L. Gautier, Adaliene V. M. Ferreira   +3 more
doaj   +1 more source

SOME PITFALLS OF EFFICIENCY IN CONTEMPORARY HIGHER EDUCATION

Journal on Efficiency and Responsibility in Education and Science, 2011
The strategic objective of the Long-Term Intent of the Czech Ministry of Education represents a fundamental change in orientation towards the development of higher education from quantity to quality, which is due to the enormous growth in students ...
KOMÁREK, Jaroslav
doaj  

A Systemic Approach to Formalized Description of Factors Affecting the Brake System Elements of Wagon Bogies

Communications
The article highlights the results of the traffic safety analysis conducted in the wagon industry of Ukrainian Railways. Based on this study, it was found that the largest number of transport accidents are caused by the braking equipment of wagons.
Sergii Panchenko, Juraj Gerlici, Alyona Lovska, Vasyl Ravlyuk   +3 more
doaj   +1 more source

Study of the Distribution of Normal Contact Pressure Between Parts Joined in a Multi-Bolted System under Operational Loads

Engineering Transactions, 2019
Modelling and calculations of unsymmetrical multi-bolted connections treated as a system for different bolt models and contact layer models between the joined parts are presented. The modelling refers to preloaded and externally loaded connections.
Rafał GRZEJDA
doaj   +1 more source

Could Inflammaging and Its Sequelae Be Prevented or Mitigated? [PDF]

, 2019
Aged humans display a chronic and low-grade inflammation, termed "inflammaging", which has been potentially linked to the subsequent development of some aging-associated systemic disorders, including type 2 diabetes, atherosclerotic cardiovascular ...
Elias, Peter M, Man, Mao-Qiang
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

School Leaders in Gifted Education: Their Perceptions of Involvement of and Interacting with Parents, Teachers, and Other School Leaders

Education Sciences
Effective collaboration among various actors is essential to optimally support the educational needs of gifted students. School leaders play an essential role in creating an environment and policies that foster this collaboration.
Jessica Vergeer, Marjolijn van Weerdenburg, Trudie Schils, Anouke Bakx   +3 more
doaj   +1 more source