Results 101 to 110 of about 2,290,242 (288)

Periodontitis and systemic diseases: insights into the correlation, mechanisms, and clinical implications

Frontiers in Immunology
Periodontitis is a chronic oral infectious inflammatory disease caused by dental plaque, affecting approximately 35% - 50% of adults globally. Far from a localized oral condition, it exerts systemic pathogenic effects through multiple biological conduits.
Zhina Wu, Yaoyao Zhang, Lishan Wang, Yating Yi, Bingfeng Dai, Huanyun Chen, Fanghong Yang, Fanghong Yang   +7 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Genetic variants associated with systemic inflammatory disease associate with temporomandibular symptoms with or without periodontitis.

PLoS ONE
IntroductionAssociations of genetic polymorphisms reported to play a role in systemic inflammatory diseases may serve as proxies to assess predisposition for oral diseases, as well as identify biomarkers to support preventive measures and targeted ...
Courtney Lucas, Dylan Baxter, Kathleen Deeley, Nilesh Shah, Antonio Pugliano, Renato Silva, Ariadne Letra, Mariana Bezamat, Alejandro Almarza, Juan Taboas, Alexandre R Vieira   +10 more
doaj   +1 more source

Associations between socioeconomic factors and mental symptoms highlight whole-body correlates and pathways

iScience
Summary: Socioeconomic status (SES) correlates with both mental symptoms and systemic health traits, suggesting systemic health conditions as potential complementary pathways for SES-mental health associations alongside neural mechanisms.
Guoshu Zhao, Jie Tang, Zehao Wang, Qian Qian, Shaoying Wang, Nannan Zhang, Jinghan Sun, Hui Xue, Zuhao Sun, Yingying Xie, Zirui Wang, Huaigui Liu, Hao Ding, Feng Liu, Wen Qin, Meng Liang, Jiayuan Xu, Chunshui Yu   +17 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Associations between Systemic and Dental Diseases in Elderly Korean Population

Medicina
Background and Objectives: Modernization and population aging have increased the prevalence of systemic diseases, such as diabetes and hypertension, which are often accompanied by various dental diseases.
Se Hoon Kahm, SungEun Yang
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Systemic Associations of Exfoliation Syndrome

Asia-Pacific Journal of Ophthalmology, 2016
Exfoliation syndrome (XFS) is an age-related disease characterized by the production, deposition, and progressive accumulation of a white, fibrillar, extracellular material in many ocular tissues, most prominent on the anterior lens surface and pupillary border. Its prevalence increases steadily with age in all populations.
openaire   +2 more sources

Joint association of the inflammatory marker and cardiovascular-kidney-metabolic syndrome stages with all-cause and cardiovascular disease mortality: a national prospective study

BMC Public Health
Background Cardiovascular-kidney-metabolic (CKM) syndrome and systemic inflammation significantly contribute to mortality. However, the joint associations of CKM stages and systemic inflammation with all-cause and cardiovascular disease (CVD) mortality ...
Yifei Cao, Wenfeng Wang, Shidong Xie, Yanfang Xu, Zishan Lin   +4 more
doaj   +1 more source