Results 81 to 90 of about 355,486 (262)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Association between systemic immune-inflammation index and urinary incontinence: Evidence from the National Health and Nutrition Examination Survey

Journal of International Medical Research
Objective This study examined the association between the systemic immune-inflammation index and urinary incontinence subtypes using data from National Health and Nutrition Examination Survey 2007–2016.
Feike Ma, Zhi-Cheng Cong, Hao Zhang, Yi-Han Chen, Yi-Lun Cui, Yue Duan, Ting-Ting Tao   +6 more
doaj   +1 more source

Periodontitis and systemic diseases: insights into the correlation, mechanisms, and clinical implications

Frontiers in Immunology
Periodontitis is a chronic oral infectious inflammatory disease caused by dental plaque, affecting approximately 35% - 50% of adults globally. Far from a localized oral condition, it exerts systemic pathogenic effects through multiple biological conduits.
Zhina Wu, Yaoyao Zhang, Lishan Wang, Yating Yi, Bingfeng Dai, Huanyun Chen, Fanghong Yang, Fanghong Yang   +7 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Genetic variants associated with systemic inflammatory disease associate with temporomandibular symptoms with or without periodontitis.

PLoS ONE
IntroductionAssociations of genetic polymorphisms reported to play a role in systemic inflammatory diseases may serve as proxies to assess predisposition for oral diseases, as well as identify biomarkers to support preventive measures and targeted ...
Courtney Lucas, Dylan Baxter, Kathleen Deeley, Nilesh Shah, Antonio Pugliano, Renato Silva, Ariadne Letra, Mariana Bezamat, Alejandro Almarza, Juan Taboas, Alexandre R Vieira   +10 more
doaj   +1 more source

Associations between socioeconomic factors and mental symptoms highlight whole-body correlates and pathways

iScience
Summary: Socioeconomic status (SES) correlates with both mental symptoms and systemic health traits, suggesting systemic health conditions as potential complementary pathways for SES-mental health associations alongside neural mechanisms.
Guoshu Zhao, Jie Tang, Zehao Wang, Qian Qian, Shaoying Wang, Nannan Zhang, Jinghan Sun, Hui Xue, Zuhao Sun, Yingying Xie, Zirui Wang, Huaigui Liu, Hao Ding, Feng Liu, Wen Qin, Meng Liang, Jiayuan Xu, Chunshui Yu   +17 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Associations between Systemic and Dental Diseases in Elderly Korean Population

Medicina
Background and Objectives: Modernization and population aging have increased the prevalence of systemic diseases, such as diabetes and hypertension, which are often accompanied by various dental diseases.
Se Hoon Kahm, SungEun Yang
doaj   +1 more source