Results 71 to 80 of about 349,014 (261)

Migraine In Systemic Lupus Erythematosus in Rheumatological outpatients unit

مجله كليه طب الكندي, 2019
Background: Migraine is common in systemic lupus erythematosus.It is a significant source of patient disability. Objective: To determine the rate of migraine in patients with systemic lupus erythematosus, to assess migraine type, severity, and the ...
Ameer Shaker
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Toxic Mix of Multiculturalism and Medicine: The Credentialing and Professional-Entry Experience for Persons of African Descent

Genealogy
This essay is based on a case study of international medical graduates (IMGs) in Canada who migrated from sub-Saharan Africa. The chapter examines how narratives of race are situated and deployed in the field of medicine and can produce some aversive ...
Lorne Foster
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Investigating the link between oral health conditions and systemic diseases: A cross-sectional analysis

Scientific Reports
This study investigates the association between oral health issues, specifically periodontitis and dental caries, and systemic health conditions such as diabetes and hypertension.
Priyadarshini Natarajan, Samaneh Madanian, Sarah Marshall   +2 more
doaj   +1 more source

AUTOANTIBODIES IN SYSTEMIC SCLEROSIS: SPECTRUM, CLINICAL ASSOCIATIONS, AND PROGNOSTIC VALUE

Научно-практическая ревматология, 2016
The purpose of the review is to clinically evaluate circulating autoantibodies in systemic sclerosis (SS). The diseasespecific, i.e. disease-associated, antinuclear autoantibodies: to centromeres, to topoisomerase 1; a group of antinuclear antibodies to ...
L. P. Ananyeva, E. N. Aleksandrova
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Associations between systemic inflammation and cognitive trajectories post-stroke

Scientific Reports
Our objective was to explore whether plasma inflammatory biomarkers and related metabolites in acute phase and 3 months after stroke were associated with different cognitive trajectories and with changes in cognition post-stroke.
Heidi Vihovde Sandvig, Ingvild Saltvedt, Trine Holt Edwin, Stina Aam, Katinka Nordheim Alme, Rannveig Sakshaug Eldholm, Stian Lydersen, Tom Eirik Mollnes, Ragnhild Munthe-Kaas, Per Magne Ueland, Arve Ulvik, Torgeir Wethal, Anne-Brita Knapskog   +12 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source