Results 61 to 70 of about 2,290,242 (288)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Associative systems of left quotients

Journal of Algebra, 2005
Taking as starting point the idea that the study of maximal quotient systems (the analogues of the maximal quotient ring) for associative pairs and triple systems could shed light on the structure theory of Jordan systems (algebras, pairs or triples) and of Lie algebras, the authors develop a theory for these quotient systems.
Aranda Pino, Gonzalo, Siles Molina, Mercedes   +1 more
openaire   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Women of Color for Systemic Change. Harmony Wright interview

, 2017
Interview with Harmony Wright of Women of Color for Systemic ...
Coronel, Micaela, Wright, Harmony
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Correlation between Pseudoexfoliation Syndrome and Hyperlipidemia in Patients Attending Shahid Aso Eye Hospital: A Comparative Clinical Study

Advanced Medical Journal
Background and Objectives:  Pseudoexfoliation (PXF) syndrome is a prevalent age-associated disorder with glaucoma and various other ocular issues. Recent evidence suggests a possible association between PXF and systemic conditions like hyperlipidemia ...
Zhino Mohammed, Bakhtiar Hama Salh
doaj   +1 more source

Novel IL10 gene family associations with systemic juvenile idiopathic arthritis [PDF]

, 2006
Juvenile idiopathic arthritis (JIA) is the most common cause of chronic childhood disability and encompasses a number of disease subgroups. In this study we have focused on systemic JIA (sJIA), which accounts for approximately 11% of UK JIA cases.
Woo, P, Samuel, JM, Gutierrez, Ana, Lewis, C M; id_orcid, Lewis, CM, Woo, Patricia, Samuel, J M, Fife, M S, Ogilvie, Emma M., Carmel JW Stock, Fife, MS, Lewis, Cathryn M., Emma M Ogilvie, Ogilvie, EM, Ana Gutierrez, Mack, LF, Fife, Mark S., Samuel, Jane M., Thomson, W, Cathryn M Lewis, Mark S Fife, Mack, L F, Mack, Lisa F., Ogilvie, E M, Gutierrez, A, Jane M Samuel, Stock, CJW, Stock, C J W, Stock, Carmel J W, Wendy Thomson, Thomson, Wendy, Patricia Woo, Lisa F Mack   +32 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source