Results 51 to 60 of about 1,462,017 (310)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Psychosocial effects of systemic sclerosis: A case report

Nursing Practice Today, 2020
“…Sit down. Look at the TV. Move slowly. Wait for death.” Background & Aim: Systemic sclerosis or scleroderma is a rare chronic connective tissue disease included among autoimmune rheumatic diseases.
Esra Oksel
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB As Novel Risk Loci for Systemic Sclerosis [PDF]

, 2011
Systemic sclerosis (SSc) is an orphan, complex, inflammatory disease affecting the immune system and connective tissue. SSc stands out as a severely incapacitating and life-threatening inflammatory rheumatic disease, with a largely unknown pathogenesis ...
P. Amouyel, MELCHERS I, Cusi, D., Amouye, Philippe, Jerome Avouac, Melchers, Inga, Salvi Erika, Müller, Martina, ALLANORE Y, Damjanov Nemanja, Meyer Oliver, HACHULLA E, Nemanja Damjanov, Hunzelmann Nicolas, I. Melchers, H.-Erich Wichmann, Wichmann, H.-E., Ulf Müller-Ladner, Lambert, J.C., Ruiz, B., AMOUYEL P, Munnich, A., Riemekasten, Gabriella, Cracowski Jean-Luc, Distler, J.H., AVOUAC J, CONTI C, Hachulla Eric, Dupuy, Anne-Marie, Dieude, Philippe, AIRO P, Munnich Arnold, Caramaschi, Paola, Avouac, Jerome, Nicolas Hunzelmann, Inga Melchers, Lambert J. C, Allanore, Y., C. Boileau, Conti, Costanza, Diot, Elisabeth, Lambert Jean-Charles, A. M. Dupuy, O. Meyer, Yannick Allanore, Avouac, J., Martinez, Maria, Ruiz Barbara, Otylia Kowal Bielecka, Wichmann, H-Erich, Luc Letenneur, J. Avouac, P. Caramaschi, Mouthon Luc, Wipff, J., Wichmann, H.-Erich, Dieudé Philippe, C. Conti, Meyer, O., E. Hachulla, M. Müller, Mouthon, L., Arnold Munnich, Avouac Jérôme, Damjanov, Nemanja, Gabriele Valentini, Valentini, G., Müller-Ladner Ulf, Caramaschi Paola, Müller, M., Tiev, Kiet, Martinez, M., Meyer, Oliver, MARTINEZ M., Kowal-Bielecka, O., H. Erich Wichmann, Distler, Jorg, H. W., A. Munnich, Matucci-Cerinic Marco, Dupuy Anne Marie, László Czirjak, G. Valentini, DAMJANOV N, MEYER O, Kahan, Andre, Melchers Inga, RICCIERI V, Saad, M., Jorg H W Distler, Cusi Daniele, Ruiz, Barbara, Kahan André, Martina Muller, E. Salvi, WIPFF J, E. Diot, Distler J, Müller Martina, CARAMASCHI P, DIOT E, Erika Salvi, J. C. Lambert, HUNZELMANN N, Matucci-Cerinic, M., Boileau, Catherine, Dieudé, P., Airo, P., Cusi, Daniele, Riccieri, Valeria, Müller-Ladner, U., J. Wipff, L. Czirják, Distler, Jorg H. W., Hachulla, E., Czirjak, Laszlo, Czijak L, Y. Allanore, MUNNICH A, Mohamad Saad, Czirják, L., Wipff, Julien, K. Tiev, L. Letenneur, Letenneur, Luc, Maria Martinez, Conti Costanza, Airo Paolo, Kowal-Bielecka, Otylia, N. Damjanov, MÜLLER LADNER U, SALVI E, WICHMANN HE, Valentini Gabriele, Jorg H. W. Distler, Paolo Airo, DUPUY AM, Valentini G, CUSI D, MÜLLER M, Mouthon, Luc, J. L. Cracowski, Damjanov, N., LAMBERT JC, Distler Jorg H. W., H-Erich Wichmann, P. Dieudé, Diot, E., MATUCCI CERINIC, Marco, Paola Caramaschi, Valentini, Gabriele, Hachulla, Eric, Jean Luc Cracowski, Tiev Kiet, CRACOWSKI JL, Airo, Paolo, Costanza Conti, Jean-Charles Lambert, RUIZ B, Daniele Cusi, Martinez Maria, Valeria Riccieri, M. Matucci Cerinic, MATUCCI CERINIC M, Eric Hachulla, H. E. Wichmann, Lambert, Jean-Charles, Wichmann, Heinz-Erich, Tiev, K., Kiet Tiev, Catherine Boileau, MOUTHON L, Riemekasten, G., Jean Charles Lambert, L. Mouthon, Caramaschi, P., Marco Matucci-Cerinic, SAAD M, B. Ruiz, Riemekasten Gabriella, J. H. Distler, BOILEAU C, Boileau Catherine, Philippe Amouyel, Riccieri Valeria, Munnich, Arnold, Cracowski, Jean-Luc, Gabriella Riemekasten, DIEUDÉ P, N. Hunzelmann, Saad Mohamad, Letenneur Luc, Czirják László, Allanore, Yannick, Philippe Dieude, Julien Wipff, Müller-Ladner, Ulf, KOWAL BIELECKA O, LETENNEUR L, Kowal-Bielecka Otylia, Elisabeth Diot, G. Riemekasten, KAHAN A, Wichmann H.-Erich, Salvi, E., Matucci-Cerinic, Marco, Dupuy, A.M., D.M. Cusi, Oliver Meyer, U. Müller Ladner, Hunzelmann, Nicolas, Allanore Yannick, Wipff Julien, Cracowski, J.L., Saad, Mohamad, Barbara Ruiz, RIEMEKASTEN G, O. Kowal Bielecka, Conti, C., M. Martinez, Jean-Luc Cracowski, P. Airo, CZIRJÁK L, Amouyel, Philippe, Letenneur, L., Salvi, Erika, DISTLER JH, Amouyel, P., Distler, Jorg,, Luc Mouthon, V. Riccieri, Hunzelmann, N., Ulf Muller Ladner, TIEV K, Dupuy, Anne Marie, Diot Elisabeth, Kahan, A., Riccieri, V., Marco Matucci Cerinic, André Kahan, Boileau, C., M. Saad, A. Kahan, Anne Marie Dupuy, Amouyel Philippe, Otylia Kowal-Bielecka, Melchers, I.   +245 more
core   +1 more source

From Tears to Toxins: Mapping Antibiotic Passage Through the Eye–Liver Axis

Antibiotics
Traditionally used to combat infections, systemic effects of antibiotics are increasingly recognized in the context of absorption through unconventional routes. One such as the ocular surface.
Ivan Šoša
doaj   +1 more source

Chitosan Effects on Plant Systems

International Journal of Molecular Sciences, 2016
Chitosan (CHT) is a natural, safe, and cheap product of chitin deacetylation, widely used by several industries because of its interesting features. The availability of industrial quantities of CHT in the late 1980s enabled it to be tested in agriculture.
Malerba, M, Cerana, R.
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Bilateral spontaneous dislocation of posterior chamber intraocular lens in a patient with gyrate atrophy

Indian Journal of Ophthalmology, 2012
We report a patient with gyrate atrophy, a rare metabolic disease, who had bilateral late spontaneous posterior dislocation of in-the-bag posterior chamber intraocular lens (PCIOL). He underwent pars plana vitrectomy, PCIOL retrieval and anterior chamber
Michael Kinori, Howard Desatnik, Joseph Moisseiev   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The effects of inspiratory muscle training in older adults

, 2015
Purpose: Declining inspiratory muscle function and structure and systemic low-level inflammation and oxidative stress may contribute to morbidity and mortality during normal ageing.
Mills, Dean E., Dean E. Mills (16661205), Yvonne A. Barnett (16661208), Johnson, Michael A., Barnett, YA, Mills, DE, Sharpe, GR, Sharpe, Graham R., Graham R. Sharpe (16661214), Smith, William H. T., William H. T. Smith (16661211), Johnson, MA, Barnett, Yvonne A., Smith, WHT, Michael A. Johnson (1317849)   +14 more
core   +1 more source