Results 61 to 70 of about 1,462,017 (310)

Short-term outcome of Boston Type 1 keratoprosthesis for bilateral limbal stem cell deficiency

Indian Journal of Ophthalmology, 2012
This study reports the short-term functional and anatomical outcome of Boston Type 1 keratoprosthesis (Boston Kpro) implantation for bilateral limbal stem cell deficiency (LCSD).
Sayan Basu, Mukesh Taneja, Raja Narayanan, Sirisha Senthil, Virender S Sangwan   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Proinflammatory Cytokines: Possible Accomplices for the Systemic Effects of Clostridioides difficile Toxin B

Journal of Inflammation Research, 2021
Katia Fettucciari,1 Alessandro Fruganti,2 Andrea Marchegiani,2 Stefano Brancorsini,1 Pierfrancesco Marconi,1 Gabrio Bassotti3,4 1Department of Experimental Medicine, University of Perugia Medical School, Perugia, Italy; 2School of Biosciences and ...
Fettucciari K, Fruganti A, Marchegiani A, Brancorsini S, Marconi P, Bassotti G   +5 more
doaj  

Effect of dacryocystorhinostomy on systemic adverse effects of topical timolol maleate

Indian Journal of Ophthalmology, 2012
Purpose: To evaluate whether transformation of the naso-lacrimal passage as happens after dacryocystorhinostomy (DCR) operation has any effect on the systemic adverse effects of topically administered timolol maleate.
Kakoli Roy, Kanchan Kumar Mondal, Biswarup Ray, Soumen Chakraborty, Supreeti Biswas, Bijoy Kumar Baral   +5 more
doaj   +1 more source

The Role of Systemic Antimicrobials in the Treatment of Endophthalmitis: A Review and an International Perspective

Ophthalmology and Therapy, 2020
Background The optimal management of patients with endophthalmitis is challenging and includes both intravitreal and, in some cases, systemic antimicrobials. Systemic antimicrobials may be administered either intravenously or orally.
Andrzej Grzybowski, Magdalena Turczynowska, Stephen G. Schwartz, Nidhi Relhan, Harry W. Flynn   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Comparison of systemic effects of midazolam, ketamine, and isoflurane anaesthesia in rabbits

Journal of Veterinary Research, 2019
Introduction: Clinical doses of anaesthetic agents were administered to rabbits and effects on the brain, heart, and liver were investigated biochemically and histopathologically.
Atalan Güneri, Atalan Gültekin, Erol Hanifi, Erol Muharrem, Atasever Ayhan, Doğan Zafer, Güneş Vehbi, Yönez M. Kaan, Keleş Ihsan   +8 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Systemic side effects of eye drops: a pharmacokinetic perspective

, 2016
Andre Farkouh,1 Peter Frigo,2 Martin Czejka1,3 1Division of Clinical Pharmacy and Diagnostics, Faculty of Life Sciences, University of Vienna, 2Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, 3Austrian ...
Frigo P, Farkouh A, Czejka M
core  

Lack of the long pentraxin PTX3 promotes autoimmune lung disease but not glomerulonephritis in murine systemic lupus erythematosus. [PDF]

, 2011
The long pentraxin PTX3 has multiple roles in innate immunity. For example, PTX3 regulates C1q binding to pathogens and dead cells and regulates their uptake by phagocytes. It also inhibits P-selectin-mediated recruitment of leukocytes.
Mantovani Alberto, Heni Eka Susanti, Adriana Migliorini, A. Migliorini, Susanti, Heni Eka, Hans-Joachim Anders, Christoph Römmele, Kulkarni, Onkar P., M. Lech, Cecilia Garlanda, Kulkarni Onkar P., Lech, Maciej, Lech Maciej, Garlanda Cecilia, C. Garlanda, Römmele, Christoph, Migliorini Adriana, Mantovani, Alberto, Alberto Mantovani, Anders Hans-Joachim, Onkar P Kulkarni, Maciej Lech, Susanti Heni Eka, A. Mantovani, Anders, Hans-Joachim, Römmele Christoph, H.E. Susanti, Migliorini, Adriana, O.P. Kulkarni, C. Römmele, H. J. Anders, Garlanda, Cecilia, Onkar P. Kulkarni   +32 more
core   +1 more source