Results 81 to 90 of about 1,462,017 (310)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Therapeutic effects of physostigmine during systemic inflammation

, 2018
Katharina Effenberger-Neidnicht,1 Johannes Jägers,2 Rabea Verhaegh,1 Michael Kirsch1 1Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany; 2Institute of Physiology, University Hospital Essen, Essen, Germany Introduction ...
Effenberger-Neidnicht K, Verhaegh R, Kirsch M, Jägers J   +3 more
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Cannabis and Health: Exploring Risks, Benefits and Research Horizons

Advances in Human Biology
Cannabis is the most widely used illicit substance globally, with its psychoactive compound, Delta-9-tetrahydrocannabinol (THC), exerting significant systemic effects. Upon consumption, tetrahydrocannabinol (THC) rapidly enters the bloodstream, affecting
Murali Punniakotti, Rahnuma Ahmad, James Villanueva, Tushar Roy, Keagan Mohammed, Dahiru Sani, Shegufta Mohammad, Manu Sundaram, Mainul Haque, Sayeeda Rahman   +9 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

How Do Banking Supervisors Deal with Europe-wide Systemic Risk? [PDF]

The systemic risk potential in the European banking market has increased. Hence, the following questions emerge: Is there a need for a truly European supervisory framework? And, how should a potential European supervisor be organised?
Schüler, Martin
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Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Effect and mode of action of some systemic nematicides

, 1975
In this study, nematicidal effects, mode of action and specific characters of some systemic nematicides were studied, in search of substitutes for the widely used soil fumigants that require high dosages.
Bunt, J.A.
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Systemic risk in the financial sector; a review and synthesis [PDF]

In a financial crisis, an initial shock gets amplified while it propagates to other financial intermediaries, ultimately disrupting the financial sector.
Michiel Bijlsma, Jeroen Klomp, Sijmen Duineveld   +2 more
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Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy [PDF]

, 2011
The aim of this study was to determine, through a genome-wide association study (GWAS), the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc).
Kreuter, A, Riel, P.L.C.M. van, V. Fonollosa, Baere, E. de, Chee, MM, Herrick Ariane, Arnett FC, M. F. González Escribano, A. T. Lee, Voskuyl AE, Nelson JL, Ortego-Centeno, N., Martin Jose-Ezequiel, Vanthuyne M, Hesselstrand Roger, González-Escribano, María F, Houssiau, F., Hesselstrand, Roger,, B. Z. Alizadeh, Spanish Scleroderma Grp, Wigley, Frederick M., Riemekasten, Gabriella, B. A. Lie, Wigley Frederick M., Voskuyl Alexandre E., Shiels, P.G., Alizadeh, Behrooz Z., van Riel, Piet L. C. M., Varga, J., Hesselstrand, Roger, Gregersen Peter K., Arnett, F. C., Hummers J., Westhovens Rene, Vanthuyne, M., Teruel, M., Padyukov, Leonid, Jacob van Laar, Teruel M, van Laar J, Italiaander, A, Kreuter, Alexander, Airó, Paolo, Scorza, Raffaella, Coenen Marieke J. H., Hesselstrand, R, Ortego Centeno N, Hummers, J, J. E. Martin, Gourh, Pravitt, A. Italiaander, A. E. Voskuyl, Francisco J García-Hernández, Maureen D Mayes, Díaz-Gallo, L. M., Torsten Witte, Arnett, FC, M. Vanthuyne, Assassi, Shervin, Martin, Javier, Ortego-Centeno Norberto, Nelson, JL, A. M. Hoffmann Vold, Martin, J.E., Christopher P. Denton, Kreuter, A., Carreira, P., J Lee Nelson, Hummers, Laura K., Lee, A.T., Broen, Jasper C, Riel, P.L. van, Westhovens R, Radstake, T. R., Shiels, Paul G., Peter K. Gregersen, Alizadeh Behrooz Z., Vonk, M.C., Lorenzo Beretta, Agarwal S, Hunzelmann N, De Keyser, FilipUGent801000564576976124243025F423C6B4-F0ED-11E1-A9DE-61C894A0A6B4, Tan, F.K., de Keyser, F, Vanessa Smith, Ruben van 't Slot, Shervin Assassi, Rajan Madhok, Worthington J, Norberto Ortego-Centeno, J. Ying, Arnett, Frank C., van Riel, PL, J. van Laar, A. J. Schuerwegh, Alizadeh, B.Z., Hoffmann-Vold, A.M., F. Houssiau, de Keyser Filip, Martin, J-E., Palm, Øyvind, González-Gay, Miguel A., Herrick, A., Nordin, A, Ophoff, Roel A, Simeon, Carmen P, Agarwal, Sandeep, Piet L. C. M. van Riel, Nelson, J Lee, Monique Hinchcliff, R. van't Slot, Roel A Ophoff, Chee Meng May, González-Escribano, MF, Chee MM, Laar, Jacob M. van, Broen JC, Riel, Piet L.C.M. van, Roger Hesselstrand, Tan Filemon K., P. Gourh, Carmen P. Simeon, Keyser, F. de, Koeleman, BP, Beretta, Lorenzo, Javier Martin, Fonollosa V, Hoffmann-Vold, A. M., Wigley, Frederick M, Hoffmann-Vold, A-M., Olga Gorlova, Westhovens, R., Radstake, Timothy RDJ, Broen Jasper C., Chee, Meng May, Nelson, J. Lee, Gorlova Olga, Carmen P Simeon, De Baere, ElfrideGE31UZGent8010010929250000-0002-5609-6895F50FFF8E-F0ED-11E1-A9DE-61C894A0A6B4, Varga, John, Nordin A, Bobby P C Koeleman, Hummers Laura K., Chee, M.M., Raffaella Scorza, Sandeep Agarwal, Voskuyl, Alexandre E., Houssiau, Fredric, Claudio Lunardi, C. P. Denton, Benedicte A Lie, R. A. Ophoff, Denton, CP, Koeleman, Bobby P C, Teruel, M, Marie Vanthuyne, Palm O, María F. González-Escribano, Palm Øyvind, van't Slot, Ruben, Simeón, Carmen P., Espinosa Garriga, Gerard, Shiels, Paul G, F. K. Tan, Schuerwegh Annemie J., F. C. Arnett, Witte T, Tan FK, van Laar, J, Martin, JE, Denton, C., Anna-Maria Hoffmann-Vold, Nordin, A., Alizadeh, Behrooz Z, Houssiau F, Italiaander, A., Laar, J. van, Fonseca, C, Riemekasten G, Paolo Airo, Oyvind Palm, Vicente Fonollosa, Vanthuyne Marie, García-Hernández, Francisco José, Paloma García de la Peña, Fonollosa, Vicente, Gourh P, Fonseca Carmen, Lund University., F. de Keyser, Herrick, Ariane, Madhok, R., Scorza, R., Piet L C M van Riel, Fonseca, Carmen, Mayes, MD, Hinchcliff Monique, Carreira, P, Worthington, J., R. Scorza, Teruel, María, María F González-Escribano, Fredric Houssiau, Beretta, L., Paul G Shiels, Agarwal, S, Agarwal Sandeep, Madhok, R, Gregersen, PK, Christopher I. Amos, Ophoff, Roel A., van Riel PL, Martin, J., Frank C Arnett, Lunardi Claudio, Assassi, S, Lunardi, Claudio, Shiels, P., Ortego-Centeno, N, E. de Baere, Arnett, Frank C, T. R. Radstake, Annemie J. Schuerwegh, Hoffmann-Vold Anna-Maria, Hoffmann Vold AM, Westhovens, Rene, van Riel, P., Fonseca C, Arnett, F.C., Diaz-Gallo, L.M., Christopher I Amos, Hummers, LK, Padyukov, L, McCarthy, M.I., Witte, T., Riemekasten, G., Gregersen, Peter K, J. Lee Nelson, Coenen, Marieke JH, Lee AT, Ying Jun, R. Madhok, Riemekasten Gabriella, Fonollosa, V., Behrooz Z. Alizadeh, Amos CI, Assassi Shervin, Hoffmann-Vold, Anna Maria, Koeleman, Bobby PC, Gabriella Riemekasten, González-Escribano, María Francisca, P. K. Gegersen, Denton, Christopher P., Ariane Herrick, Jasper C Broen, van Riel Piet L. C. M., Nelson, J.L., B. Rueda, Alexander Kreuter, Bobby P. C. Koeleman, Vonk, Madelon C, Fonseca, C., Wigley, F. M., Hinchcliff M, Diaz-Gallo, Lina Marcela, Denton CP, Marieke J. H. Coenen, Assassi, S., Smith, VanessaGE35UZGent0019912577298020000091300000-0001-6271-7945F83FAD26-F0ED-11E1-A9DE-61C894A0A6B4, García-Hernández, F.J., Rueda, B., van Riel, P.L.C.M., van 't Slot Ruben, Elfride de Baere, van 't Slot, R, Simeon Carmen P., González-Gay, MA, J. C. Broen, P. Airo, Miguel A. González-Gay, Lie Benedicte A., García de la Peña P, C. P. Simeon, van't Slot, R., Hinchcliff, M., Broen, J.C., Gregersen PK, Rueda B, García de la Peña, P., Øyvind Palm, Shiels PG, Hunzelmann, N., Amos, Christopher I., A. Kreuter, Witte, T.J.M. de, de Baere, E., P. García de la Peña, Ophoff, R.A., González-Escribano María F., Koeleman, B. P., van Laar Jacob, Timothy R. D. J. Radstake, Smith V, Schuerwegh, AJ, Radstake, Timothy R D J, van Laar, Jacob, Mayes, Maureen D, Schuerwegh, A. J., Lee, Annette T., Gorlova, O, González-Gay Miguel A., Amos, CI, Baere, Elfride De, Diaz Gallo LM, Peter K Gregersen, Mayes MD, R. Hesselstrand, de la Pena, P.G., Madelon C Vonk, Vanthuyne, Marie, Padyukov Leonid, Radstake, Timothy R. D. J., Hunzelmann Nicolas, de la Peña Paloma, García P., Amos Christopher I., García Hernández FJ, Denton, C.P., de Baere, E, Gregersen, Peter K., González-EscribanoMarí, María F., Pena, P.G. de la, Gourh Pravitt, Houssiau, Frédéric, García de la Peña Paloma, Mayes, Maureen D., Fonollosa, V, Gonzalez-Escribano, Maria F., Lie, BA, null null, Jasper C. Broen, V. Smith, Maureen D. Mayes, Madelon C. Vonk, Radstake TR, Herrick, A, García de la Peña, Paloma, John Varga, N. Ortego Centeno, Fonollosa Vicente, Vonk, MC, Nordin Annika, Carreira P, Hesselstrand, R., Carreira, Patricia E., Martin, Jose-Ezequiel, Koeleman, B.P., Smith, V., Annet Italiaander, Gorlova, O., Nicolas Hunzelmann, Lie, Benedicte A., M. C. Vonk, Diaz-Gallo, L., Hesselstrand R, M. J. Coenen, O. Palm, González Gay MA, Mayes Maureen D., Diaz-Gallo, Lina-Marcela, Behrooz Z Alizadeh, Madhok, Rajan, Lie, B.A., Simeon, CP, Hummers, Laura K, Herrick A, Laura K. Hummers, S. Assassi, Slot, R. van 't, J. L. Nelson, Alizadeh BZ, Hummers, J., Diaz-Gallo, LM, Hunzelmann, N, Gourh, P, Shiels, PG, Pravitt Gourh, Frank C. Arnett, Smith Vanessa, Frederick M Wigley, Annette T. Lee, Radstake, T., Agarwal, Sandeep K., Kreuter A, Coenen, MJ, P. L. van Riel, de Baere Elfride, González-Gay, M.A., Voskuyl, AE, Wigley, F.M., Westhovens, R, Meng May Chee, Scorza R, Lie, Benedicte A, Arnett Frank C., Vonk MC, Beretta, L, Hummers, L. K., Mayes, M.D., Padyukov L, Witte, Torsten, Airo, P, Carreira, Patricia, Broen, JC, Denton Christopher P., Coenen, M., Schuerwegh AJ, Ying, J, Witte, T, T. Witte, Simeon CP, Radstake Timothy R. D. J., Alexandre E Voskuyl, P. G. Shiels, Schuerwegh, Annemie J, Italiaander, Annet, Shiels Paul G., Lee, AT, Jane Worthington, Teruel Maria, Hummers, L.K., Broen, J.C.A., Madhok R, García-Hernández, Francisco J., Martín, J. E., Vonk Madelon C., Maria Teruel, Varga, J, Lunardi, C, Koeleman BP, Assassi S, L. M. Diaz Gallo, García-Hernández Francisco J., Wigley, FM, Marieke J H Coenen, C. Lunardi, J. Martin, Madhok Rajan, Martin, Jose Ezequiel, Palm, Ø., Benedicte A. Lie, van Riel, Piet L C M, A. Herrick, Francisco J. García-Hernández, Schuerwegh, A.J., Witte Torsten, Nelson J. Lee, Ophoff Roel A., Christopher P Denton, De Baere, Elfride, M. Hinchcliff, Gorlova, Olga, M. A. González Gay, Voskuyl, A.E., Airo, P., Worthington, Jane, Coenen, Marieke J. H., Ying J, Palm, Oyvind, Tan, FK, Amos, Christopher I, González-Escribano, M.F., Voskuyl, Alexandre E, González-Gay, Miguel A, Alexandre E. Voskuyl, Gourh, P., Blanca Rueda, C. I. Amos, Varga John, Airo Paolo, Lee, Annette T, Tan, F., Broen, Jasper C., Ying, J., Coenen, Marieke J H, Lunardi, C., Alizadeh, BZ, Simeon, C.P., van Riel, Piet LCM, Fonollosa Pla, Vicent, Italiaander Annet, Coenen, M.J.H., Timothy R D J Radstake, González Escribano MF, Beretta L, F. M. Wigley, van 't Slot R, van 't Slot, Rubén, Carreira Patricia, Lie BA, Italiaander A, Slot, R. van't, Annemie J Schuerwegh, M. Teruel, Palm, O, Tan, Filemon K., Hinchcliff, M, Kreuter Alexander, Smith, V, Filemon K Tan, Varga J, Gregersen, P.K., Leonid Padyukov, Annika Nordin, Houssiau Fredric, Radstake, TR, Rueda Blanca, García de la Peña, P, P. Carreira, Nelson, J. L., Ying, Jun, Jun Ying, Laura K Hummers, Palm, O., Martin, J, Smith, Vanessa, Carmen Fonseca, M. D. Mayes, Ophoff, RA, Filip de Keyser, Patricia Carreira, Hinchcliff, Monique, Miguel A González-Gay, Coenen MJ, Coenen, M. J., Ortego-Centeno, Norberto, Martin J., van 't Slot, R., Koeleman Bobby P. C., Spanish Scleroderma Study Group (SSSG), Radstake, T.R.D.J., Rene Westhovens, Airo P, Worthington, J, N. Hunzelmann, A. Nordin, L. K. Hummers, S. Agarwal, de Baere E, L. Padyukov, Ophoff RA, Riemekasten, G, García-Hernández, FJ, De Keyser, Filip, O. Gorlova, M. M. Chee, Diaz-Gallo Lina-Marcela, Lee Annette T., G. Riemekasten, de Keyser, F., Rueda, Blanca, Martin JE, Ophoff, R. A., Lie, B. A., J. Worthington, Koeleman, Bobby P. C., Vonk, Madelon C., Lina-Marcela Diaz-Gallo, Hunzelmann, Nicolas, Gorlova O, García-Hernández, Francisco J, Filemon K. Tan, Nordin, Annika, Paul G. Shiels, C. Fonseca, Schuerwegh, Annemie J., Jose-Ezequiel Martin, Beretta Lorenzo, de Keyser F, Denton, Christopher P, Simeón Aznar, Carmen Pilar, Frederick M. Wigley, Vanthuyne, M, Agarwal, S., Martin Javier, Scorza Raffaella, Houssiau, F, Hoffmann-Vold, AM, J. Varga, Scorza, R, B. P. Koeleman, Annette T Lee, Hoffmann-Vold, Anna-Maria, van Laar, J., L. Beretta, Koeleman, B.P.C., Padyukov, L., Hummers LK, Wigley FM, F. J. García Hernández, Rueda, B, Worthington Jane, Spanish Scleroderma Group, Alizadeh, B. Z., R. Westhovens, J. Hummers, Amos, C.I., Tan, Filemon K, Roel A. Ophoff   +607 more
core   +1 more source