Results 91 to 100 of about 310,934 (303)
Chapter Five. Systematic review results by biomarker classifications [PDF]
, 2016 5.1 Markers of Absorption and Permeability Overview 5.2 Markers of Absorption 5.3 Markers of Permeability 5.4 Markers of Digestion 5.5 Markers of Intestinal Inflammation and Intestinal Immune Activation 5.6 Markers of Systemic Inflammation and Systemic ...
Denno, Donna M +4 more
core +1 more source
Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer [PDF]
, 2016 In patients with colorectal cancer (CRC), local and systemic inflammatory responses have been extensively reported to associate with cancer survival. However, the specific signalling pathways responsible for inflammatory responses are not clear. The PTEN/
Bennett, Lindsay +7 more
core +3 more sources
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Frontiers in Public HealthBackgroundSedentary behavior (SB), has been closely linked to numerous detrimental health effects. While the individual and combined impacts of such behaviors on immune-inflammatory responses remain ambiguous, innovative indices like the Systemic Immune ...
Xian Wu +6 more
doaj +1 more source
Pattern recognition receptors as key players in adrenal gland dysfunction during sepsis [PDF]
, 2012 Background: Undergoing systemic inflammation, the innate immune system releases excessive proinflammatory mediators, which finally can lead to organ failure. Pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and NOD-like receptors (
Bornstein, Stefan R. +4 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Evaluation of pseudoexfoliation syndrome patients with systemic immune indexes
BMC OphthalmologyPurpose The aim of this study was to investigate the level of peripheral blood systemic immune indexes in pseudoexfoliation syndrome (PXS) patients and to compare the results with healthy controls.
Ömer Özer, Emin Serbülent Güçlü
doaj +1 more source
A Review of Ankylosing Spondylitis [PDF]
, 2017 Ankylosing spondylitis (AS) is a systemic autoimmune disorder that induces ankylosis of the spine (fusion of the vertebrae at their various joints) and inflammatory arthritis of peripheral joints among other symptoms.
Owen, Hannah L
core +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Emergency Care JournalCOVID-19 can cause a wide range of effects on patients, from asymptomatic cases to mortality. Many factors can affect the prognosis of the disease. Our study aims to evaluate the predictive power of the Systemic Inflammatory Index (SII) and Systemic ...
Alikemal Topal +5 more
doaj +1 more source