The systemic immune-inflammation index in the efficacy prediction of neoadjuvant chemotherapy in patients with endometrial cancer. [PDF]
Transl Cancer ResLin J +4 more
europepmc +1 more source
CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads
Advanced Healthcare Materials, EarlyView.In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura +4 more
wiley +1 more source
Correlation analysis of the systemic immune-inflammation index with preoperative lower extremity deep venous thrombosis in patients with tibial fractures. [PDF]
J Orthop Surg ResYang A +7 more
europepmc +1 more source
Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice
Advanced Healthcare Materials, EarlyView.A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec +5 more
wiley +1 more source
Prognostic value of systemic immune-inflammation index and prognostic nutritional index in advanced prostate cancer: development and validation of a comprehensive nomogram. [PDF]
BMC CancerLi G, Li B, Zhang X, Jia J.
europepmc +1 more source
Systemic immune-inflammation index as a novel predictor of major adverse cardiovascular events in patients undergoing percutaneous coronary intervention: a meta-analysis of cohort studies [PDF]
Chunyu Zhang +8 more
openalex +1 more source
Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration
Advanced Healthcare Materials, EarlyView.Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu +4 more
wiley +1 more source
Comments on "Association of systemic immune-inflammation index with adverse outcomes in heart failure and preserved ejection fraction". [PDF]
J Transl MedShao J, Zhu C, Yin J.
europepmc +1 more source