Results 81 to 90 of about 310,934 (303)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Evaluation of the Systemic Immune-Inflammation Index and Systemic Inflammatory Response Index in Ankylosing Spondylitis Patients

İstanbul Medical Journal, 2023
Introduction: The aim of this study was to investigate the relationship between the Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) and disease activity in patients with ankylosing spondylitis (AS).
Burak Tayyip Dede, Berat Bulut, Muhammed Oğuz, Fatih Bağcıer, Ebru Aytekin   +4 more
doaj   +1 more source

Clinicopathological determinants of an elevated systemic inflammatory response following elective potentially curative resection for colorectal cancer [PDF]

, 2017
Introduction: The postoperative systemic inflammatory response (SIR) is related to both long- and short-term outcomes following surgery for colorectal cancer.
Horgan, Paul G., McMillan, Donald C., McSorley, Stephen T., Park, James H., Ramanathan, Michelle L., Walley, Killian, Watt, David G.   +6 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A retrospective observational study on the prognostic role of inflammatory markers in futile recanalization after endovascular treatment for large-vessel stroke

Journal of International Medical Research
Objective Endovascular treatment has proven to be effective in improving the outcome of patients with large-vessel stroke. However, more than half of the patients experience poor outcomes despite successful recanalization, which was defined as futile ...
Zubing Xu, Linghong Guo, Yunqing Chen, Dandan Chen, Hudie Zhang, Xilin Xiong, Yan Gong, Qiulong Yu, Chenying Zeng, Lanjiao Zhang, Qin Huang, Jinchong Zhang, Keji Zou, Pu Fang, Daojun Hong, Jing Lin, Xian Liu, Xiaobing Li   +17 more
doaj   +1 more source

Relationship between emergency presentation, systemic inflammatory response, and cancer-specific survival in patients undergoing potentially curative surgery for colon cancer [PDF]

, 2009
Background Emergency presentation is recognized to be associated with poorer cancer-specific survival following curative resection for colorectal cancer.
Canna, Carstairs, Crumley, Donald C. McMillan, Du Clos, E. Fiona Leitch, Forrest, Franch-Arcas, Gibbs, Glen, Heys, Heys, Hole, John H. Anderson, Joseph E.M. Crozier, Leitch, Longo, Longo, McArdle, McArdle, McMillan, McMillan, McMillan, McMillan, McMillan, Nielsen, Nozoe, Paul G. Horgan, Phillips, Preston, Ruth F. McKee, Scott, Vermeire, Ytting   +33 more
core   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Microbiota, Oral Microbiome, and Pancreatic Cancer [PDF]

, 2014
Only 30% of patients diagnosed with pancreatic cancer survive one year post-diagnosis. Progress in understanding the causes of pancreatic cancer has been made, including solidifying the associations with obesity and diabetes, and a proportion of cases ...
Izard, Jacques, Michaud, Dominique S.
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The Role of Systemic Immune-Inflammation Index and Systemic Inflammation Response Index in the Diagnosis of Bell’s Palsy

Journal of Behçet Uz Children's Hospital
Objective: Recent studies showed that Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI) can be used as inflammatory markers.
Betül Öztürk, Raziye Merve Yaradılmış, Muhammed Mustafa Güneylioğlu, Ali Güngör, İlknur Bodur, Aytaç Göktuğ, Orkun Aydın, Meltem Akçaboy, Ergin Atasoy, Can Demir Karacan, Nilden Tuygun   +10 more
doaj   +1 more source