Results 101 to 110 of about 3,045,517 (253)

PCIC Corporate Report 2024-2025 [PDF]

The Pacific Climate Impacts Consortium's Corporate Report for 2024 ...
Pacific Climate Impacts Consortium
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Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

PCIC corporate report 2015-2016 [PDF]

, 2016
The Pacific Climate Impacts Constortium (PCIC) corporate report for 2015 ...
Pacific Climate Impacts Consortium (PCIC)
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Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Impacts of Inflammatory Cytokines Variants on Systemic Inflammatory Profile and COVID-19 Severity

Journal of Epidemiology and Global Health
Background Cytokine storm is known to impact the prognosis of coronavirus disease 2019 (COVID-19), since pro-inflammatory cytokine variants are associated with cytokine storm.
XueJun Deng, Kai Tang, Zhiqiang Wang, Suyu He, Zhi Luo   +4 more
doaj   +1 more source

Hypothesis: Potentially Systemic Impacts of Elevated CO₂ on the Human Proteome and Health. [PDF]

Front Public Health, 2020
Duarte CM, Jaremko Ł, Jaremko M.
europepmc   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Gaucher disease type 3 from infancy through adulthood: a conceptual model of signs, symptoms, and impacts associated with ataxia and cognitive impairment

Orphanet Journal of Rare Diseases
Background Gaucher disease type 3 (GD3) is a lysosomal storage disease characterized by diverse neurological and systemic manifestations. Symptoms of ataxia, cognitive impairment, and other systemic symptoms profoundly impact daily activities and the ...
Raphael Schiffmann, James Turnbull, Robert Krupnick, Ruth Pulikottil-Jacob, Chad Gwaltney, Alaa Hamed, Isabela Batsu, Walter Heine, Eugen Mengel   +8 more
doaj   +1 more source

Climate extremes in the Columbia basin: Summary report

, 2014
Anthropogenic climate change could potentially bring with it a variety of impacts, among them, impacts due to changes in weather and climate extremes.
Pacific Climate Impacts Consortium (PCIC)
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PCIC science brief: Climate impacts on specialty fruit and grazing in the Pacific Northwest [PDF]

, 2018
Two recent articles in the journal Climatic Change examine some of the effects that climate change may have on agriculture in the Pacific Northwest. Focusing on specialty fruit production, Houston et al.
Pacific Climate Impacts Consortium (PCIC)
core