Results 101 to 110 of about 3,323 (218)

Impacts of Inflammatory Cytokines Variants on Systemic Inflammatory Profile and COVID-19 Severity

Journal of Epidemiology and Global Health
Background Cytokine storm is known to impact the prognosis of coronavirus disease 2019 (COVID-19), since pro-inflammatory cytokine variants are associated with cytokine storm.
XueJun Deng, Kai Tang, Zhiqiang Wang, Suyu He, Zhi Luo   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Identifying and addressing the components of extreme physical-oceanographical events for improved risk management in coastal systems

Frontiers in Marine Science
Extreme physical-oceanographic events, such as marine heatwaves, fluvial floods, droughts and storm surges, have major impacts on local communities, economic sectors and ecosystems, and their frequency, intensity and duration increase due to climate ...
Eric P. Achterberg, Fabian Rackelmann, Ananya Ramesh, Jack O’Connor, Ovidio García-Oliva, Saranya Jayachandran, Viktoria Wichert, Xiangyu Li, Kaveh Purkiani, David M. Needham, Ingeborg Bussmann, Philipp Fischer, Achim Kopf, Carsten Lemmen, Jörn Peter Scharsack, Christian Siebert, Norbert Kamjunke, Inna M. Sokolova, Inna M. Sokolova, Holger Brix   +19 more
doaj   +1 more source

The Impact of the Euro on Information Systems

Journal of Information Systems, 1999
The European Economic Union (EEU) adopted a single currency, the “euro” on January 1, 1999. Such a development has far-reaching implications for development of information systems, the engines that will have to run and control the new monetary order. For example, euro-compliant systems will need to accommodate: (1) six decimal places, a major change ...
openaire   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Macroeconomic policy coordination and its influence on systemic risk and economic growth: evidence from China

Cogent Economics & Finance
We examine the coordinated effects of fiscal, monetary, and macroprudential policies in the context of China’s macroeconomic regulation and financial risk management.
Xuyang Ma, Mingzhu Zhu
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Surgical treatment of varicose veins reduces leg edema and generalized edema: Alleviating clinical symptoms throughout the body

Vascular Investigation and Therapy
Edema presents itself in two primary forms: generalized edema and localized edema. Previous studies suggest that varicose veins contribute to systemic edema. We investigated if treating them could alleviate symptoms elsewhere.
Shinji Tomita, Yutaka Koyama, Masahiro Inagaki, Satoki Ozoe   +3 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source