Results 111 to 120 of about 223,207 (264)

Impacts of Inflammatory Cytokines Variants on Systemic Inflammatory Profile and COVID-19 Severity

Journal of Epidemiology and Global Health
Background Cytokine storm is known to impact the prognosis of coronavirus disease 2019 (COVID-19), since pro-inflammatory cytokine variants are associated with cytokine storm.
XueJun Deng, Kai Tang, Zhiqiang Wang, Suyu He, Zhi Luo   +4 more
doaj   +1 more source

Macroeconomic policy coordination and its influence on systemic risk and economic growth: evidence from China

Cogent Economics & Finance
We examine the coordinated effects of fiscal, monetary, and macroprudential policies in the context of China’s macroeconomic regulation and financial risk management.
Xuyang Ma, Mingzhu Zhu
doaj   +1 more source

Hypothesis: Potentially Systemic Impacts of Elevated CO₂ on the Human Proteome and Health. [PDF]

Front Public Health, 2020
Duarte CM, Jaremko Ł, Jaremko M.
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Identifying and addressing the components of extreme physical-oceanographical events for improved risk management in coastal systems

Frontiers in Marine Science
Extreme physical-oceanographic events, such as marine heatwaves, fluvial floods, droughts and storm surges, have major impacts on local communities, economic sectors and ecosystems, and their frequency, intensity and duration increase due to climate ...
Eric P. Achterberg, Fabian Rackelmann, Ananya Ramesh, Jack O’Connor, Ovidio García-Oliva, Saranya Jayachandran, Viktoria Wichert, Xiangyu Li, Kaveh Purkiani, David M. Needham, Ingeborg Bussmann, Philipp Fischer, Achim Kopf, Carsten Lemmen, Jörn Peter Scharsack, Christian Siebert, Norbert Kamjunke, Inna M. Sokolova, Inna M. Sokolova, Holger Brix   +19 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Surgical treatment of varicose veins reduces leg edema and generalized edema: Alleviating clinical symptoms throughout the body

Vascular Investigation and Therapy
Edema presents itself in two primary forms: generalized edema and localized edema. Previous studies suggest that varicose veins contribute to systemic edema. We investigated if treating them could alleviate symptoms elsewhere.
Shinji Tomita, Yutaka Koyama, Masahiro Inagaki, Satoki Ozoe   +3 more
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source