Results 111 to 120 of about 3,045,517 (253)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Identifying and addressing the components of extreme physical-oceanographical events for improved risk management in coastal systems

Frontiers in Marine Science
Extreme physical-oceanographic events, such as marine heatwaves, fluvial floods, droughts and storm surges, have major impacts on local communities, economic sectors and ecosystems, and their frequency, intensity and duration increase due to climate ...
Eric P. Achterberg, Fabian Rackelmann, Ananya Ramesh, Jack O’Connor, Ovidio García-Oliva, Saranya Jayachandran, Viktoria Wichert, Xiangyu Li, Kaveh Purkiani, David M. Needham, Ingeborg Bussmann, Philipp Fischer, Achim Kopf, Carsten Lemmen, Jörn Peter Scharsack, Christian Siebert, Norbert Kamjunke, Inna M. Sokolova, Inna M. Sokolova, Holger Brix   +19 more
doaj   +1 more source

Life Cycle Assessment in Spatial Planning:A Procedure for Addressing Systemic Impacts

, 2015
Spatial planning establishes conditions for societal patterns of production and consumption. However, the assigned Strategic Environmental Assessments (SEA) tend to have a too narrow focus. In particular, there is a need for applying a system perspective
Bidstrup, Morten, Schmidt, Jannick Højrup; id_orcid, Pizzol, Massimo; id_orcid   +2 more
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Macroeconomic policy coordination and its influence on systemic risk and economic growth: evidence from China

Cogent Economics & Finance
We examine the coordinated effects of fiscal, monetary, and macroprudential policies in the context of China’s macroeconomic regulation and financial risk management.
Xuyang Ma, Mingzhu Zhu
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Surgical treatment of varicose veins reduces leg edema and generalized edema: Alleviating clinical symptoms throughout the body

Vascular Investigation and Therapy
Edema presents itself in two primary forms: generalized edema and localized edema. Previous studies suggest that varicose veins contribute to systemic edema. We investigated if treating them could alleviate symptoms elsewhere.
Shinji Tomita, Yutaka Koyama, Masahiro Inagaki, Satoki Ozoe   +3 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Structural integrity: Recognizing, measuring, and addressing systemic racism and its health impacts

EClinicalMedicine, 2021
Renée Boynton-Jarrett, Anita Raj, David J. Inwards-Breland   +2 more
doaj   +1 more source