Results 71 to 80 of about 3,045,517 (253)

Inflammation impairs post-hospital discharge growth among children hospitalised with acute illness in sub-Saharan Africa and south Asia

open access: yesNature Communications
In resource-limited settings, children often experience poor growth following illness, but the mechanisms are poorly understood. This cohort study in six countries in sub-Saharan Africa and south Asia investigates pathways linking inflammation and post ...
James M. Njunge   +34 more
doaj   +1 more source

Ending the Document Game: Connecting and Transforming Your Healthcare Through Information Technlogy

open access: yes, 2005
The Commission on Systemic Interoperability was authorized by the Medicare Modernization Act and established by the Secretary of Health and Human Services. Its members were appointed by the President of the United States of America and the leaders of the
Commission on Systemic Interoperability
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Measuring systemic risk [PDF]

open access: yes
We present a simple model of systemic risk and show how each financial institution’s contribution to systemic risk can be measured and priced.
Lasse H. Pedersen   +3 more
core  

PCIC corporate report 2020-2021 [PDF]

open access: yes, 2021
The Pacific Climate Impacts Constortium (PCIC) corporate report for 2020 ...
Pacific Climate Impacts Consortium (PCIC)
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The future of atmospheric rivers and actions to reduce impacts on British Columbians

open access: yes, 2014
To improve local understanding and manage the impacts of atmospheric river events, the B.C. Ministry of Environment commissioned work to summarize the current state of knowledge pertaining to BC on this topic and conduct a multi-agency qualitative risk ...
Pinna Sustainability   +1 more
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Collective action for systemic change: Pathways, dynamics, and impacts

open access: yes
PowerPoint presentation for the symposium “Collective action for systemic change: Pathways, dynamics, and impacts”, June 17Centre for Development and Environment (CDE) - Just Economies & Human Well BeingCentre for Development and Environment ...
Sach, Anna   +5 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

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