Results 211 to 220 of about 861,769 (248)

PTSD, Immune System, and Inflammation

2023
Posttraumatic stress disorder (PTSD) is a severe trauma and stress-related disorder associated with different somatic comorbidities, especially cardiovascular and metabolic disorders, and with chronic low-grade inflammation. Altered balance of the hypothalamic-pituitary-adrenal (HPA) axis, cytokines and chemokines, C-reactive protein, oxidative stress ...
Nela, Pivac, Barbara, Vuic, Marina, Sagud, Gordana, Nedic Erjavec, Matea, Nikolac Perkovic, Marcela, Konjevod, Lucija, Tudor, Dubravka, Svob Strac, Suzana, Uzun, Oliver, Kozumplik, Sandra, Uzun, Ninoslav, Mimica   +11 more
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Central nervous system inflammation

European Journal of Anaesthesiology, 2008
Activation of inflammation is the hallmark of pathological processes that follow acute injury. This process is mediated by inflammatory cytokines and adhesion molecules that reside on the surface of endothelium, leucocyte and inflammatory cells. Attenuation of the adhesion cascade has been the subject of several basic science and clinical trials in the
S G, Soriano, S, Piva
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Systemic inflammation after trauma

Injury, 2007
Trauma is still one of the main reasons for death among the population worldwide. Mortality occurring early after injury is due to "first hits", including severe organ injury, hypoxia, hypovolaemia or head trauma. Massive injury leads to activation of the immune system and the early inflammatory immune response after trauma has been defined as systemic
Andreas, Lenz, Glen A, Franklin, William G, Cheadle   +2 more
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Apelin/APJ system in inflammation

International Immunopharmacology, 2022
Apelin, an endogenous ligand for the G protein-coupled receptor (APJ), is widely distributed within the central nervous system and diverse organs in human and animals. Recent studies indicate that the apelin/APJ system plays an important role in physiological and pathophysiological situations.
Xu Wang, Lu Zhang, Peisen Li, Yafei Zheng, Yanjie Yang, Shaoping Ji   +5 more
openaire   +2 more sources

Systemic inflammation induces axon injury during brain inflammation

Annals of Neurology, 2011
AbstractObjective:Axon injury is a key contributor to the progression of disability in multiple sclerosis (MS). Systemic infections, which frequently precede relapses in MS, have been linked to clinical progression in Alzheimer's disease. There is evidence of a role for the innate immune system in MS lesions, as axonal injury is associated with ...
Moreno, Beatriz, Jukes, John-Paul, Vergara-Irigaray, Nuria, Errea, O., Villoslada, Pablo, Perry, V.H., Newman, T.A.   +6 more
openaire   +4 more sources

Systemic inflammation and Alzheimer's disease

Biochemical Society Transactions, 2011
A number of studies demonstrate disturbances of the central innate immune system in AD (Alzheimer's disease). In animal and human studies, there is evidence of close communication between systemic and central innate immune systems. Animal models of neurodegeneration show evidence of an exaggerated central innate immune response following systemic ...
Clive, Holmes, Joe, Butchart
openaire   +2 more sources

Spinal opioid systems in inflammation

Inflammation Research, 1995
Until recently, basic science studies, both behavioural and electrophysiological, have concentrated on the antinociceptive actions of opioids primarily gauged against acute nociceptive responses. However, of more relevance to clinical situations are the actions of opioids in more persistent/prolonged pain states.
L, Stanfa, A, Dickenson
openaire   +2 more sources

Systems Biology and Inflammation

2010
Inflammation is a complex, multiscale biological response to threats - both internal and external - to the body, which is also required for proper healing of injured tissue. In turn, damaged or dysfunctional tissue stimulates further inflammation.
Yoram, Vodovotz, Gary, An
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Systemic inflammation in the elderly

Best Practice & Research Clinical Anaesthesiology, 2011
Inflammation is an adaptive response to surgery. When the pro-inflammatory responses are unregulated and become over reactive, systemic inflammatory response syndrome may occur. Postoperative systemic inflammation is more common than is generally acknowledged and is observed in about 10-15% of elderly patients undergoing major surgery.
Emily G Y, Koo, Linda M L, Lai, Gordon Y S, Choi, Matthew T V, Chan   +3 more
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Systemic Response to Inflammation

Nutrition Reviews, 2007
The systemic inflammatory response represents a coordinated set of physiologic actions that serve to fight infection, heal wounds, and promote recovery from external stressors. Thus, under most circumstances an intact systemic inflammatory response increases the likelihood of a successful outcome following acute injury or infection.
openaire   +2 more sources