Results 81 to 90 of about 900,908 (297)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Intestinal Barrier Dysfunction in the Absence of Systemic Inflammation Fails to Exacerbate Motor Dysfunction and Brain Pathology in a Mouse Model of Parkinson's Disease [PDF]

, 2022
Aeja Jackson, Phillip A. Engen, Christopher B. Forsyth, Maliha Shaikh, Ankur Naqib, Sherry Wilber, Dulce M. Frausto, Shohreh Raeisi, Stefan J. Green, Brinda Desai Bradaric, Amanda L. Persons, Robin M. Voigt, Ali Keshavarzian   +12 more
openalex   +1 more source

IgE-Mast cell mediated allergy: a sensor of food quality

Signal Transduction and Targeted Therapy, 2023
Christopher C. Udoye, Rudolf A. Manz
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

More damaging than we think: Systemic effects of intestinal inflammation [PDF]

, 2009
Aya M. Westbrook, Bo Wei, Jonathan Braun, Robert H. Schiestl   +3 more
openalex   +1 more source

Mapping Pulmonary and Systemic Inflammation in Preschool Aged Children With Cystic Fibrosis [PDF]

, 2021
Shivanthan Shanthikumar, Sarath Ranganathan, Richard Saffery, Melanie R. Neeland   +3 more
openalex   +1 more source

Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation

Journal of Neuroinflammation, 2018
Background Microglia function is essential to maintain the brain homeostasis. Evidence shows that aged microglia are primed and show exaggerated response to acute inflammatory challenge.
Joana Costa d’Avila, Luciana Domett Siqueira, Aurélien Mazeraud, Estefania Pereira Azevedo, Debora Foguel, Hugo Caire Castro-Faria-Neto, Tarek Sharshar, Fabrice Chrétien, Fernando Augusto Bozza   +8 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Involvement of Interleukin‐1β in Systemic Morphine Effects on Paw Oedema in a Mouse Model of Acute Inflammation [PDF]

, 2004
Zahra Pourpak, Abolhasan Ahmadiani, M. Alebouyeh   +2 more
openalex   +1 more source

The relationship between systemic inflammation, body composition and clinical outcomes in patients with operable colorectal cancer at low and medium to high nutritional risk [PDF]

, 2020
Tanvir Abbass, Ross D. Dolan, Paul G. Horgan, Donald C. McMillan   +3 more
openalex   +1 more source