Results 81 to 90 of about 290,641 (235)

Associations between SII, SIRI, and cardiovascular disease in obese individuals: a nationwide cross-sectional analysis

Frontiers in Cardiovascular Medicine
BackgroundSystemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) are comprehensive markers of inflammatory status.
Zhou Liu, Longxuan Zheng
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Impact of systemic immune inflammation index and systemic inflammation response index on all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome

European Journal of Medical Research
Background The cardiovascular-kidney-metabolic (CKM) syndrome is a systemic condition defined by multifaceted interactions among metabolic risk factors, chronic kidney disorder, and cardiovascular diseases.
Yongwei Huang, Xiaoshuang Yin, Zongping Li   +2 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Association between systemic immune-inflammation index, systemic inflammation response index, and adverse outcomes in aneurysmal subarachnoid hemorrhage: a meta-analysis

Frontiers in Neurology
PurposeThis systematic review seeks to explore the link of the systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI), to adverse outcomes (AOs) in aneurysmal subarachnoid hemorrhage (aSAH).
Yihong Hao, Jianfang Zhao, Jie Han, Dajiang Hao   +3 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Correlation of systemic immune inflammation index and systemic inflammatory response index with the severity of Parkinson’s disease

Frontiers in Neurology
Background While the significance of inflammation in Parkinson’s disease (PD) pathogenesis has been established, the relevance of emerging hematological markers such as the systemic immune-inflammation index (SII) and systemic inflammatory response index (SIRI) to this disorder requires further investigation.
Li, Fangyi, Wang, Zhen, Deng, Mingzhu, Peng, Jian, He, Guohua, Tong, Yangping, Xu, Wei, Feng, Tieqiao, Song, Kangping   +8 more
openaire   +2 more sources

Evaluation of systemic immune-inflammation index and systemic inflammation response index in the differentiation of acute Ischemic stroke and transient Ischemic attack

Malawi Medical Journal
Objective The aim of this study was to examine the levels of hematologic parameters in acute ischemic stroke (AIS) and transient ischemic attack (TIA) and to evaluate the use of Neutrophil/Lymphocyte ratio (NLR), Systemic Immune-Inflammation Index (SII), and systemic inflammation response index (SIRI) in the differentiation of AIS and TIA.Materials and
YILMAZ, Mustafa, USLU, Muhammad Fuad, ATESCELİK, Metin, ATILGAN, Fethi Ahmet   +3 more
openaire   +3 more sources