Results 41 to 50 of about 736,102 (303)

Effect of Xenon on Proinflammatory Activation and Apoptosis of Human Neutrophils Under Ex Vivo Conditions

Неотложная медицинская помощь, 2021
Background. The syndrome of systemic inflammatory response, which underlies the damaging effect of factors of infectious and non-infectious genesis, may cause multiple organ failure.
O. A. Grebenchikov, A. K. Shabanov, L. L. Nikolayev, A. I. Shpichko, I. V. Bratishchev, L. Yu. Marchenko, Sh. Zh. Khusainov, R. A. Cherpakov, N. P. Shpichko   +8 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Síndrome da resposta inflamatória sistêmica: denominação possivelmente aplicável a fenômenos dermatológicos Systemic inflammatory response syndrome: a denomination possibly applied to dermatological phenomena

Anais Brasileiros de Dermatologia, 2007
A síndrome da resposta inflamatória sistêmica consiste na resposta inflamatória aguda mediada por fatores inflamatórios relacionada a sepse e traumatismos extensos.
Maria de Fátima de Medeiros Brito
doaj   +1 more source

Systemic inflammatory response syndrome after pediatric congenital heart surgery: Incidence, risk factors, and clinical outcome

Journal of cardiac surgery, 2017
Systemic inflammatory response syndrome (SIRS) is frequent after cardiac surgery, but data on its incidence and perioperative risk factors are scarce for children with congenital heart disease.
M. Boehne, M. Sasse, A. Karch, Friederike Dziuba, A. Horke, T. Kaussen, R. Mikolajczyk, P. Beerbaum, T. Jack   +8 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Severity of Systemic Inflammatory Response Syndrome Affects the Blood Levels of Circulating Inflammatory-Relevant MicroRNAs

Frontiers in Immunology, 2018
The systemic inflammatory response syndrome (SIRS) is a potentially lethal response triggered by diverse forms of tissue injury and infection. When systemic inflammation is triggered by infection, the term sepsis is used.
Stefano Caserta, M. Mengozzi, F. Kern, S. Newbury, P. Ghezzi, Martin J. Llewelyn   +5 more
semanticscholar   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Systemic inflammatory response syndrome in Sepsis-3: a retrospective study

BMC Infectious Diseases, 2019
Background In the new Sepsis-3 definition, sepsis is defined as “life-threatening organ dysfunction due to a dysregulated host response to infection.” We tested the predictive validity of the systematic inflammatory response syndrome (SIRS) criteria in ...
Wei Zhang, Yan Zheng, Xiaoting Feng, Miao Chen, Yan Kang   +4 more
doaj   +1 more source

A Case of Systemic Inflammatory Response Syndrome after Liposuction-assisted Abdominoplasty

Plastic and Reconstructive Surgery, Global Open, 2021
Summary. A 51-year-old woman underwent liposuction-abdominoplasty. After surgery, she developed hypotension and bradycardia, attributed to iatrogenic opioid-intoxication.
Sophie A. Riesmeijer, MD, Berend van der Lei, MD, PhD   +1 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source