Results 51 to 60 of about 770,386 (297)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Systemic inflammatory response syndrome in Sepsis-3: a retrospective study

BMC Infectious Diseases, 2019
Background In the new Sepsis-3 definition, sepsis is defined as “life-threatening organ dysfunction due to a dysregulated host response to infection.” We tested the predictive validity of the systematic inflammatory response syndrome (SIRS) criteria in ...
Wei Zhang, Yan Zheng, Xiaoting Feng, Miao Chen, Yan Kang   +4 more
doaj   +1 more source

Ticagrelor induced systemic inflammatory response syndrome [PDF]

BMC Cardiovascular Disorders, 2017
Ticagrelor is a reversible and direct-acting oral antagonist of the adenosine diphosphate receptor P2Y12. Possible adenosine-mediated effects of ticagrelor on inflammation are complex and incompletely understood. To our knowledge, ticagrelor-induced systemic inflammatory response syndrome (SIRS) has not yet been described.We report the case of an 84 ...
Krisai P, Haschke M, Buser PT, Mueller C
openaire   +3 more sources

Validation of a Host Response Assay, SeptiCyte LAB, for Discriminating Sepsis from Systemic Inflammatory Response Syndrome in the ICU

American Journal of Respiratory and Critical Care Medicine, 2018
Rationale: A molecular test to distinguish between sepsis and systemic inflammation of noninfectious etiology could potentially have clinical utility.
Russell R. Miller, B. Lopansri, J. Burke, M. Levy, S. Opal, R. Rothman, F. D’Alessio, V. Sidhaye, N. Aggarwal, R. Balk, J. Greenberg, M. Yoder, G. Patel, Emily R. Gilbert, M. Afshar, J. Parada, G. Martin, A. Esper, J. Kempker, M. Narasimhan, Adey Tsegaye, Stella S. Hahn, P. Mayo, T. van der Poll, M. Schultz, B. Scicluna, P. K. Klouwenberg, Antony Rapisarda, T. Seldon, L. Mchugh, T. Yager, S. Cermelli, D. Sampson, V. Rothwell, R. Newman, S. Bhide, B. Fox, J. Kirk, Krupa Arun Navalkar, R. Davis, R. Brandon, R. Brandon   +41 more
semanticscholar   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Systemic inflammatory response syndrome: a case of septic shock

Emergency Care Journal, 2008
An elderly, diabetic male, with severe sepsis, swiftly treated with antibiotics that were efficacious in vitro against the E. Coli isolated in his blood, rapidly slides into multiple organ dysfunction syndrome and dies of septic shock after a month in ...
Nicolò Gentiloni Silveri, Luigi Carbone
doaj   +1 more source

A Case of Systemic Inflammatory Response Syndrome after Liposuction-assisted Abdominoplasty

Plastic and Reconstructive Surgery, Global Open, 2021
Summary. A 51-year-old woman underwent liposuction-abdominoplasty. After surgery, she developed hypotension and bradycardia, attributed to iatrogenic opioid-intoxication.
Sophie A. Riesmeijer, MD, Berend van der Lei, MD, PhD   +1 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The systemic inflammatory response syndrome: definitions and aetiology [PDF]

Journal of Antimicrobial Chemotherapy, 1998
Systemic inflammatory response syndrome (SIRS) is the clinical expression of the action of complex intrinsic mediators of the acute phase reaction. SIRS can be precipitated by events such as infection, trauma, pancreatitis, and surgery. At times, SIRS can compromise the function of various organ systems resulting in Multiple Organ Dysfunction Syndrome (
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source