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Treatment of systemic juvenile idiopathic arthritis
Nature Reviews Rheumatology, 2023Systemic juvenile idiopathic arthritis (sJIA) is an inflammatory disease with hallmarks of severe systemic inflammation, which can be accompanied by arthritis. Contemporary scientific insights set this paediatric disorder on a continuum with its counterpart, adult-onset Still disease (AOSD). Patients with sJIA are prone to complications, including life-
Claas H. Hinze +2 more
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Systemic Juvenile Idiopathic Arthritis
Pediatric Clinics of North America, 2018Systemic juvenile idiopathic arthritis (sJIA) is a distinctive subtype of juvenile idiopathic arthritis, characterized by fever and arthritis, often accompanied by rash, sometimes by generalized lymphadenopathy, hepatosplenomegaly, and serositis. The diagnosis requires adequate exclusion of infectious, oncologic, autoimmune, and autoinflammatory ...
Jennifer J Y, Lee, Rayfel, Schneider
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Systemic Juvenile Idiopathic Arthritis: A Review
Pediatric Annals, 2012CME Educational Objectives 1. Become familiar with the clinical presentation, differential diagnosis and potential complications of systemic juvenile idiopathic arthritis. 2.
Arielle D, Hay, Norman T, Ilowite
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Systemic juvenile idiopathic arthritis
Autoimmunity Reviews, 2012Systemic juvenile idiopathic arthritis (sJIA) sets well apart from all the other forms of JIA. Several observations show that sJIA is etiopathogenically different from all the other forms of JIA and has a prominent autoinflammatory component. A major role in the pathogenesis is played by two proinflammatory cytokines, interleukin-6 and interleukin-1 ...
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Giant Iliopsoas Bursitis in Systemic Juvenile Idiopathic Arthritis
Arthritis & Rheumatology, 2021A 4-year-old boy with systemic juvenile idiopathic arthritis (sJIA) relapsed while on tacrolimus and tocilizumab (TCZ). He presented with right groin pain and claudication. The patient had mild tenderness and restricted range of motion in his right hip joint on physical examination. Furthermore, no mass was palpable.
Asami Shimbo +4 more
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Systemic Juvenile Idiopathic Arthritis
2019Systemic-onset juvenile idiopathic arthritis is a complex, polygenic autoinflammatory disease affecting young individuals. It is an innate immunity-driven condition characterized by chronic, multiorganic inflammatory involvement. Typical clinical features including young age at presentation, fever, neutrophilic skin lesions, synovitis, serositis ...
Ricardo A. G. Russo +1 more
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Interleukin-1 Blockade in Systemic Juvenile Idiopathic Arthritis
Pediatric Drugs, 2020Systemic juvenile idiopathic arthritis (sJIA) is a severe disorder now linked more to autoinflammation than to autoimmunity. Clinical and laboratory evidence support the pathogenetic role of interleukin-1 (IL-1), and blockade of this cytokine has proved to be very effective in the treatment of sJIA.
Mejbri M. +3 more
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Systemic-Onset Juvenile Idiopathic Arthritis
2019Systemic juvenile idiopathic arthritis (SJIA) is a disease of unknown etiology characterized by arthritis and systemic symptoms. Evidence shows that SJIA is probably not a single disease but a diverse group of clinically and genetically distinct illnesses. It is classified both as one of the Juvenile idiopathic arthritis (JIA) categories and also among
María Martha Katsicas +1 more
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