Results 51 to 60 of about 1,405,405 (194)

Persistent Interleukin‐18 Fuels Expansion of CD38+HLA‐DR+CD8+ T Cells in Still Disease and Macrophage Activation Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease (SD) is an autoinflammatory disorder characterized by remarkably high interleukin‐18 (IL‐18) levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is associated with further
Greta Rogani, Remco G. A. Erkens, Alejandra Bodelón, Tim R. Mocking, Marein T. M. Putmans, Freya M. C. H. Huijsmans, Lyanne J. P. M. Sijbers, Aafke M. De Ligt, Maurice J. H. Van Haaren, Rianne C. Scholman, Noël M. M. Dautzenberg, Joyce I. Meesters‐Ensing, Martina Rossano, Laura Porretti, Stefan Nierkens, Francesca S. Minoia, Sebastiaan J. Vastert, Jorg van Loosdregt   +17 more
wiley   +1 more source

Defining criteria for disease activity states in systemic juvenile idiopathic arthritis based on the systemic Juvenile Arthritis Disease Activity Score [PDF]

Objective To develop and validate cutoff values in the systemic Juvenile Arthritis Disease Activity Score 10 (sJADAS10) that distinguish the states of inactive disease (ID), minimal disease activity (MiDA), moderate disease activity (MoDA), and high ...
Robasto, Francesca, Silva, Rodrigo M., Shalaby, Radwa H., Consolaro, A., Marrani, Edoardo, Villarreal, Giselle, Lotfy, Hala M., Ozen, S., Costi, Stefania, Kriulin, Ivan, Sztajnbok, Flavio, Al‐Mayouf, Sulaiman M., Abu-Zaid, M., Abu‐Rumeleih, S., Hassan, Waleed, Maggio, Maria C., Minoia, F., Civino, Adele, Montin, Davide, Tarantola, Letizia, Khubchandani, Raju, Fouad, Nermeen A., Osman, Naglaa S., Vilaiyuk, Soamarat, Filocamo, Giovanni, Pal, P., Maldar, Naziya P., Almaaitah, Hiba, Al‐Sofyani, Fuad, Bracaglia, C., El Owaidy, R., El Miedany, Yasser, Alzyoud, Raed, Pardeo, M., Khan, A., Mahgoub, Marwa Y., Patrone, Elisa, Bathia, Jigna N., Saad‐Magalhães, Claudia, Eissa, M., Lerkvaleekul, Butsabong, Simonini, Gabriele, De Benedetti, F., Katsicas, María M., Ravelli, A., Rebollo‐Gimenez, Ana I., Mosa, D., Bayindir, Yagmur, Licciardi, F., Abu‐Shady, Hend, Vyzhga, Y., Radwan, Ahmed R., Alexeeva, Ekaterina, Dvoryakovskaya, Tatyana, Marino, Achille, Nasef, S., Kostik, M., Dāvidsone, Zane, Pistorio, Angela, Adel, Yasmin, Diomeda, Federico, Alsuweiti, Motasem, Rosina, Silvia, Tabra, Samar A. A., Rossano, Martina, El‐Ghoneimy, Dalia H., Mohamed, Sheren E. M., Belozerov, Konstantin E.   +67 more
core   +1 more source

Systemic juvenile idiopathic arthritis with chronic recurrent multifocal osteomyelitis in an adolescent: A case report

SAGE Open Medical Case Reports
Chronic recurrent multifocal osteomyelitis is a rare auto-inflammatory disease in children, with only a few reports of its association with other inflammatory diseases, such as systemic juvenile idiopathic arthritis. A 15-year-old boy was admitted due to
Mohsen Jari, Sogol Alesaeidi
doaj   +1 more source

Cytokine status and hemostasis disorders in children with juvenile idiopathic arthritis

Acta Biomedica Scientifica
Juvenile idiopathic arthritis is a chronic inflammatory joint disease in children under 16 years of age associated with pathological immune response to various antigens. Probable factors are infectious and immunogenetic.
M. V. Gomellya, A. V. Mironova, T. S. Krupskaya, A. V. Tatarinova   +3 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Expert Perspective: Toward Treat‐to‐Target Management in Adult Idiopathic Inflammatory Myopathies

Arthritis &Rheumatology, Accepted Article.
Treat‐to‐target (T2T) has transformed the management of several rheumatic diseases through predefined therapeutic goals, structured disease assessment, and timely treatment adjustment. Despite major advances in the understanding and treatment of idiopathic inflammatory myopathies (IIM), a formal T2T framework for adult IIM has not yet been established.
Shiri Keret, Nantakarn Pongtarakulpanit, Rohit Aggarwal   +2 more
wiley   +1 more source

Clinical profile of juvenile idiopathic arthritis from a tertiary care hospital in Northern India

Indian Journal of Rheumatology, 2020
Background: Juvenile idiopathic arthritis (JIA) is the most common rheumatological disorder in children with wide variation in its clinical profile. Objective: The aim is to study the clinical, laboratory, radiological, and treatment profile of children ...
Arun Hegde, Suchi Acharya, Kavita Singh, Uday Bhanu Kovilapu   +3 more
doaj   +1 more source

Prevalence of pregnancy and birth outcomes following biologic exposure in immune‐mediated inflammatory diseases: A population‐based study

British Journal of Clinical Pharmacology, EarlyView.
Aims Almost 5% of pregnancies are affected by immune‐mediated inflammatory diseases (IMIDs). As treatments become available, understanding their use during pregnancy is important. We aimed to describe maternal, pregnancy and infant outcomes among IMID pregnancies exposed to biologic therapies. Methods Using the Merative™ MarketScan® Commercial Database,
Leah K. Flatman, Lisiane F. Leal, Gabra Nohmie, Anick Bérard   +3 more
wiley   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Systemic Onset Juvenile Idiopathic Arthritis (sJIA) or Still's Disease: A Diagnostic Challenge; while Presented as Fever of Unknown Origin. 2 Cases

, 2019
Systemic-onset juvenile idiopathic arthritis (sJIA) or Still's disease is a chronic inflammatory disease of unknown etiology belongs to the group of Juvenile Idiopathic Arthritis.
Fabia Hannan Mone, Gule Tajkia, Shamim Rima, Syed Khairul Amin, Soma Halder   +4 more
core   +1 more source