Results 41 to 50 of about 19,665 (228)

Clinical Case of Tocilizumab Use in a Patient with Systemic Juvenile Idiopathic Arthritis

Педиатрическая фармакология, 2016
The article presents a case of using genetically engineered biopharmaceutical tocilizumab in a child with systemic juvenile idiopathic arthritis. On the initial stage, the treatment was characterized by resistance to high doses of glucocorticoids and ...
Y. M. Spivakovskiy, Y. V. Chernenkov, A. Y. Spivakovskaya, O. V. Skupova, E. N. Shulgina   +4 more
doaj   +1 more source

Autoinflammation and autoimmunity in systemic juvenile idiopathic arthritis [PDF]

Proceedings of the National Academy of Sciences, 2015
Juvenile idiopathic arthritis (JIA) encompasses a range of phenotypes of joint inflammation that begin in childhood. The most distinctive and potentially most severe of these is systemic JIA (sJIA), an intensely inflammatory disease characterized by high spiking fevers and evanescent rashes that sometimes progresses to a devastating chronic ...
openaire   +2 more sources

IL-1 Inhibition in Systemic Juvenile Idiopathic Arthritis [PDF]

Frontiers in Pharmacology, 2016
Systemic juvenile idiopathic arthritis (sJIA) is the form of childhood arthritis whose treatment is most challenging. The demonstration of the prominent involvement of interleukin (IL)-1 in disease pathogenesis has provided the rationale for the treatment with biologic medications that antagonize this cytokine.
Giancane, Gabriella, Minoia, Francesca, Davì, Sergio, Bracciolini, Giulia, Consolaro, Alessandro, Ravelli, Angelo   +5 more
openaire   +4 more sources

Macrophage Activation Syndrome secondary to Systemic Juvenile Idiopathic Arthritis: A Case Report

Journal of Nepal Medical Association, 2021
Macrophage activation syndrome is a rare but a life threatening condition commonly associated with Systemic Juvenile Idiopathic Arthritis. Its clinical presentation includes fever, hepatosplenomegaly, hypertriglyceridemia, hypofibrinogenemia ...
Rishikesh Kafle, Anwesh Bhatta, Sumit Gami, Abhin Sapkota, Dipesh Sharma, Arabindra Yadav, Vijaya Kumar Chikanbanjar   +6 more
doaj   +1 more source

Cognitive Behavioral Therapy for Youth With Childhood‐Onset Lupus: A Randomized Clinical Trial

Arthritis Care &Research, EarlyView.
Objective Our objective was to determine the feasibility and acceptability of the Treatment and Education Approach for Childhood‐Onset Lupus (TEACH), a six‐session cognitive behavioral intervention addressing depressive, fatigue, and pain symptoms, delivered remotely to individual youth with lupus by a trained interventionist.
Natoshia R. Cunningham, Thea Senger‐Carpenter, Jocelyn Zuckerman, Michelle Adler, Mallet R. Reid, Ashley Danguecan, Luana Flores Pereira, Sarah I. Mossad, Samantha L. Ely, Khalid Abulaban, Elizabeth A. Kessler, Natalie Rosenwasser, Tamar B. Rubinstein, Ekemini A. Ogbu, Emily A. Smitherman, Alaina Miller, Taylor Abounader, Elizabeth Ross, Livie Timmerman, Dhriti Sharma, Jennifer N. Stinson, Stacy Allen, Kabita Nanda, Tala El Tal, Deborah M. Levy, Linda T. Hiraki, Hermine I. Brunner, Mathew Reeves, Steven J. Pierce, Andrea Knight   +29 more
wiley   +1 more source

Imaging of juvenile idiopathic arthritis. Part I: Clinical classifications and radiographs [PDF]

Journal of Ultrasonography, 2016
Juvenile idiopathic arthritis is the most common autoimmune systemic disease of the connective tissue affecting individuals at the developmental age. Radiography is the primary modality employed in the diagnostic imaging in order to identify changes ...
Iwona Sudoł-Szopińska, Genowefa Matuszewska, Piotr Gietka, Mateusz Płaza, Marta Walentowska-Janowicz   +4 more
doaj   +1 more source

Thalidomide for systemic onset juvenile idiopathic arthritis

Indian Pediatrics, 2013
Systemic onset juvenile idiopathic arthritis (SOJIA) is the most common autoimmune auto inflammatory disease in childhood. A sizeable number of these patients run a recalcitrant disease course, resistant to the conventional line of management, ultimately resulting in permanent disability from joint destruction, local growth deformities or iatrogenic ...
K, Sathe, R P, Khubchandani
openaire   +2 more sources

Early changes in gene expression and inflammatory proteins in systemic juvenile idiopathic arthritis patients on canakinumab therapy

, 2021
Background: Canakinumab is a human anti-interleukin-1 beta (IL-1 beta) monoclonal antibody neutralizing IL-1 beta-mediated pathways. We sought to characterize the molecular response to canakinumab and evaluate potential markers of response using samples ...
Quartier, Pierre, Gerloni, Valeria, Terreri, Maria, Ruperto, Nicolino, Brachat, Arndt H., Grom, Alexei A., Abrams, Ken, Brunner, Hermine I., Harel, Liora, Schneider, Rayfel, Martini, Alberto, McCann, Liza, Ozdogan, Huri, Valentin, Marie-Anne, Lopez-Benitez, Jorge M., Joos, Rik, Schumacher, Martin, Gram, Hermann, Rutkowska-Sak, Lidia, Wulffraat, Nico, Houghton, Kristin, Bek, Stephan, Nirmala, Nanguneri R., Kingsbury, Daniel, Brik, Riva, Lovell, Daniel J.   +25 more
core   +1 more source

High Health Care Utilization Preceding Diagnosis With Juvenile Idiopathic Arthritis

Arthritis Care &Research, EarlyView.
Objective Although early diagnosis improves long‐term outcomes, patients with juvenile idiopathic arthritis (JIA) often experience prolonged, circuitous paths to diagnosis. To inform diagnostic improvement, we sought to characterize health care utilization in the year preceding diagnosis. Methods We identified 10,021 patients with an incident diagnosis
Anna Costello, Rui Xiao, Xuemei Zhang, Jahan Jazayeri, Irit R. Rasooly, Pamela F. Weiss   +5 more
wiley   +1 more source

Trajectories of Physical Function in Canadian Children With Juvenile Idiopathic Arthritis

Arthritis Care &Research, EarlyView.
Objective We describe trajectories of physical function in children newly diagnosed with juvenile idiopathic arthritis (JIA) and identify trajectories with persisting functional impairments and associated baseline characteristics. Methods We included patients enrolled in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry ...
Clare Cunningham, Meghan McPherson, Lillian Lim, Roberta A. Berard, Matthew Berkowitz, Jean‐Philippe Proulx‐Gauthier, Brian M. Feldman, Nicole Johnson, Dax G. Rumsey, Heinrike Schmeling, Lori B. Tucker, Thomas Loughin, Kristin M. Houghton, Jaime Guzman, for the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry Investigators, David A. Cabral, Gaëlle Chédeville, Ciarán M. Duffy, Kerstin Gerhold, Jaime Guzman, Linda Hiraki, Adam M. Huber, Heinrike Schmeling, Natalie J. Shiff, Lori B. Tucker, Julie Barsalou, Daniah Basodan, Michelle Batthish, Roberta A. Berard, Nicholas Blanchette, Gilles Boire, Roxana Bolaria, Alessandra Bruns, David A. Cabral, Sarah Campillo, Tania Cellucci, Mercedes Chan, Gaëlle Chédeville, Amieleena Chhabra, Julie Couture, Paul Dancey, Jean‐Jacques De Bruycker, Erkan Demirkaya, Muhammed Dhalla, Ciarán M. Duffy, Talal El Tal, Tommy Gerschman, Jaime Guzman, Liane Heale, Julie Herrington, Kristin M. Houghton, Adan M. Huber, Andrea Human, Nicole Johnson, Roman Jurencak, Bianca Lang, Claire LeBlanc, Lillian Lim, Lily S. H. Lim, Nadia Luca, Jeanine McColl, Tara McGrath, Tamara McMillan, Megan McPherson, Paivi Miettunen, Kimberly Morishita, Honyan Ng, Jonathan Park, Jean‐Philippe Proulx‐Gauthier, Johannes Roth, Evelyn Rozenblyum, Dax G. Rumsey, Heinrike Schmeling, Rosie Scuccimarri, Gordon Soon, Rebeka Stevenson, Elizabeth Stringer, Herman Tam, Lori B. Tucker, Marinka Twilt, Ruud H. J. Verstegen, Karen Watanabe Duffy   +81 more
wiley   +1 more source