Results 101 to 110 of about 28,304 (252)

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

Neuropsychiatric Involvement in Juvenile-Onset Systemic Lupus Erythematosus

Neurology Research International, 2018
Objective. Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by multisystem involvement, including the nervous system.
Mohammad-Amin Khajezadeh, Gholamreza Zamani, Bobak Moazzami, Zahra Nagahi, Mahdie Mousavi-Torshizi, Vahid Ziaee   +5 more
doaj   +1 more source

The development and assessment of biological treatments for children [PDF]

, 2014
The development of biological agents with specific immunological targets has revolutionized the treatment of a wide variety of paediatric diseases where traditional immunosuppressive agents have been partly ineffective or intolerable.
Akobeng, Alexeeva, Alvarez, Andborn, Anink, Baldassano, Biester, Borker, Bout-Tabaku, Braun, Brennan, Brunner, Callen, Caorsi, Cezard, Choueiter, Choy, Cleary, Colombel, Crandall, De Benedetti, De Benedetti, De Cassan, Eberhard, Eleftheriou, Feagan, Fernandes, Fleischmann, Furie, Gasparetto, Gattorno, Gerloni, Giannini, Giannini, Hanauer, Hashkes, Horneff, Horneff, Horneff, Horneff, Horneff, Horneff, Hyams, Hyams, Hyams, Irvine, Jansson, Kahn, Kanakoudi-Tsakalidou, Kaneko, Kavanaugh, Kingsbury, Kok, Kuemmerle-Deschner, Kusuhara, Kutukculer, Lehman, Lehman, Lepore, Lequerre, Lin, Lofgren, Lovell, Lovell, Lovell, Lovell, Lovell, Lovell, Lowite, Luu, Mangge, Mohler, Munro, Myers, Navarra, Nigrovic, Otten, Paller, Papsdorf, Podolskaya, Prince, Prince, Quartier, Quartier, Quatrier, Robinson, Rosenbach, Rosh, Rothner, Ruemmele, Runner, Ruperto, Ruperto, Ruperto, Ruperto, Ruperto, Russell, Sakallioglu, Sandborn, Sandborn, Simard, Simonini, Southwood, Swart, Taylor, Toussi, Tynjala, Uperto, Vermeire, Viola, Wallace, Walters, Willems, Wyneski, Yokota, Yokota, Zannin, Zeft, Zulian   +118 more
core   +1 more source

Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti‐Cancer Immunity Across the Lifespan

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex plays a key role in shaping both anti‐cancer immunity and autoimmunity. Biological factors underlying sexual dimorphism have now been identified in multiple aspects of anti‐cancer immunity and autoimmunity. These factors include sex differences in hormone levels, chromosome complement, and expression of the long non‐coding RNA XIST.
Christian G. Bustillos, Esther M. Peluso, Sophia L. Cha, Melissa G. Lechner, Maureen A. Su   +4 more
wiley   +1 more source

Unmet Needs in the Pathogenesis and Treatment of Systemic Lupus Erythematosus [PDF]

, 2017
Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease with a prevalence of approximately 1 in 1000. Over the last 30 years, advances in treatment such as use of corticosteroids and immunosuppressants have improved life expectancy and ...
Bakshi, J, Rahman, A, Segura, BT, Wincup, C   +3 more
core   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, Volume 13, Issue 8, 9 February 2026.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Epileptic seizures and EEG features in juvenile systemic lupus erythematosus Crises epilépticas e características do EEG em pacientes com lúpus eritematoso sistêmico juvenil

Arquivos de Neuro-Psiquiatria, 2008
INTRODUCTION: Juvenile systemic lupus erythematosus is more incident in female affecting different systems including the central nervous system. The aim of this study was to check the incidence of seizures and electroencephalographic features in these ...
Simone Carreiro Vieira-Karuta, Izabella Celidônio Bertoldo Silva, Paulo Breno Noronha Liberalesso, Márcia Bandeira, Loris Janz Jr, Alfredo Löhr Jr   +5 more
doaj   +1 more source

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

Juvenile and juvenile-onset systemic lupus erythematosus patients: Clinical characteristics, disease activity and damage

Egyptian Pediatric Association Gazette, 2017
Background: The diagnosis of systemic lupus erythematosus (SLE) in children is challenging. The heterogeneous manifestations and disease impact on the child’s growth highlight the importance of timely diagnosis and management.
Rasha E. Gheith, Iman I. El-Gazzar, Hussein S. El Fishawy, Abeer M. Nour El-Din, Dina M.R. Bahgat, Tamer A. Gheita   +5 more
doaj   +1 more source

Use of rituximab in systemic lupus erythematosus in children: a review

Научно-практическая ревматология, 2019
Juvenile-onset  systemic lupus erythematosus (SLE) is a significant and urgent problem in the practice of pediatricians and rheumatologists  in both verifying its diagnosis and choosing treatment policies, by taking into account the features of the onset,
A. N. Arefyeva
doaj   +1 more source