Results 131 to 140 of about 64,256 (179)
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Current Treatment Options in Gastroenterology, 2003
Systemic mastocytosis is a rare clinical disorder characterized by the proliferation of mast cells, which are commonly in the skin but may be found in other body sites as well. Mast cells contain chemically active substances that, on release, produce symptoms associated with the disease.
Arjun Deb, Ayalew Tefferi
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Systemic mastocytosis is a rare clinical disorder characterized by the proliferation of mast cells, which are commonly in the skin but may be found in other body sites as well. Mast cells contain chemically active substances that, on release, produce symptoms associated with the disease.
Arjun Deb, Ayalew Tefferi
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Annual Review of Medicine, 2004
Systemic mastocytosis is a clonal disorder of the mast cell and its progenitor. The symptoms of systemic mastocytosis are due to the pathologic accumulation and activation of mast cells in various tissues such as bone marrow, skin, gastrointestinal tract, liver, and spleen.
Cem, Akin, Dean D, Metcalfe
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Systemic mastocytosis is a clonal disorder of the mast cell and its progenitor. The symptoms of systemic mastocytosis are due to the pathologic accumulation and activation of mast cells in various tissues such as bone marrow, skin, gastrointestinal tract, liver, and spleen.
Cem, Akin, Dean D, Metcalfe
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Systemic Mastocytosis in a Goat
Veterinary Pathology, 1995Systemic mastocytosis was diagnosed in a 4-year-old, female Nubian goat. Clinically, the animal was depressed and had severe macrocytic hypochromic anemia and leukopenia. Postmortem examination revealed neoplastic mast cells invading the heart, lung, liver, spleen, lymph nodes, and bone marrow. Eosinophils were frequently admixed with infiltrating mast
K N, Khan +3 more
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Aggressive systemic mastocytosis
Joint Bone Spine, 2003Systemic mastocytosis is a rare and occasionally aggressive condition that raises major diagnostic challenges. We report a case in a 72-year-old patient in whom the diagnosis of malignant mastocytosis required two bone marrow smears and three bone marrow biopsies examined using specific staining techniques.
Rachida, Inaoui +4 more
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2006
Systemic mastocytosis is a fascinating disease with diverse clinical features. There have been numerous advances in understanding the basis of clinical manifestations of this disease and of its molecular pathogenesis in the last several decades. The development of methods to study mast cell biology using cell culture and murine models has proven ...
Jamie, Robyn, Dean D, Metcalfe
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Systemic mastocytosis is a fascinating disease with diverse clinical features. There have been numerous advances in understanding the basis of clinical manifestations of this disease and of its molecular pathogenesis in the last several decades. The development of methods to study mast cell biology using cell culture and murine models has proven ...
Jamie, Robyn, Dean D, Metcalfe
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The American Journal of Surgical Pathology, 1983
The clinical, radiologic, ultrastructural, and histopathologic findings in 14 patients with systemic mastocytosis were evaluated. Seven patients had evidence of urticaria pigmentosa (UP) and seven patients presented with no recognizable cutaneous lesions.
R D, Brunning +4 more
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The clinical, radiologic, ultrastructural, and histopathologic findings in 14 patients with systemic mastocytosis were evaluated. Seven patients had evidence of urticaria pigmentosa (UP) and seven patients presented with no recognizable cutaneous lesions.
R D, Brunning +4 more
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Treatment of Systemic Mastocytosis
Immunology and Allergy Clinics of North America, 2006It is an exciting time in the treatment of systemic mastocytosis. Major advances in the past 2 decades have helped to define the molecular abnormalities associated with this disease and to delineate pathways involved in its pathogenesis. This has directly translated into the development of novel targeted therapies. These therapies hold great promise to
Todd M, Wilson +2 more
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Eosinophilia in Systemic Mastocytosis
American Journal of Clinical Pathology, 1980The diagnosis of systemic mastocytosis depends on the proper recognition of extensive mast cells infiltration in tissues. Accurate identification of the mast cells in tissues may be difficult when there is no clinical suspicion to initiate a special search for these cells.
L T, Yam, C F, Yam, C Y, Li
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MALIGNANT SYSTEMIC MASTOCYTOSIS
Australian and New Zealand Journal of Medicine, 1988Abstract:Malignant systemic mastocytosis is a rare disorder, a subgroup of the mast cell neoplasms. Its clinical and histological diagnosis is often difficult, especially in patients without cutaneous involvement. We report an unsuspected case who underwent laparotomy complicated by life‐threatening hypotension consistent with vasoactive mediator ...
S M, Jane, R, Sutherland, H H, Salem
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Cimetidine in Systemic Mastocytosis
Drug Intelligence & Clinical Pharmacy, 1981A 54-year-old caucasian woman with systemic mastocytosis manifested by gastrointestinal and dermatological symptoms that were treated with cyproheptadine, Lomotil® (diphenoxylateatropine), and cimetidine was studied. The patient consented to discontinue the H 2 -receptor antagonist, and to ...
Mary J. Berg +3 more
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