Results 61 to 70 of about 2,227,240 (299)

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Regulating Systemic Risk [PDF]

The failure to spot emerging systemic risk and prevent the current global financial crisis warrants a reexamination of the approach taken so far to crisis prevention. The paper argues that financial crises can be prevented, as they build up over time due
Kawai, Masahiro, Pomerleano, Michael
core   +4 more sources

Photovoltaic installations are extensively deployed in areas at risk of extremely low production

Communications Earth & Environment
Photovoltaic (PV) installations have rapidly and extensively been deployed worldwide as a promising alternative renewable energy source. However, weather anomalies could expose them to challenges in supply security by causing very low power production ...
Qianzhi Wang, Kai Liu, Wei Xie, Tariq Ali, Jinshan Wu, Ming Wang   +5 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Estimating Global Wheat Yields at 4 km Resolution during 1982–2020 by a Spatiotemporal Transferable Method

Remote Sensing
Reliable and spatially explicit information on global crop yield has paramount implications for food security and agricultural sustainability. However, most previous yield estimates are either coarse-resolution in both space and time or are based on ...
Zhao Zhang, Yuchuan Luo, Jichong Han, Jialu Xu, Fulu Tao   +4 more
doaj   +1 more source

AuditChain: A Trading Audit Platform Over Blockchain

Frontiers in Blockchain, 2020
A blockchain architecture and solution is proposed to audit processing under exchange regulation for trading activity of exchanges. A particular focus is made on dark pools and periodic auctions.
Guy R. Vishnia, Guy R. Vishnia, Gareth W. Peters, Gareth W. Peters, Gareth W. Peters   +4 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Divergent responses of forest canopy height to environmental conditions across China

Ecological Indicators
As major components of terrestrial ecosystems, forest ecosystems play an important role in sequestering carbon and hence mitigating climate change. Canopy height is a crucial factor characterizing the structure and function of forest ecosystems, yet the ...
Xiang Pan, Junjie Ji, Kailin Gao, Tao Wei, Mingzhu He, Xiaohan Zhang   +5 more
doaj   +1 more source

Age‐Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice

Aging and Cancer, EarlyView.
Our findings reveal that age‐related changes in subcutaneous melanoma growth and immunotherapy response are context‐dependent. In models where tumor growth and treatment resistance increase with age, this effect is partly driven by enhanced immunosuppression from myeloperoxidase‐active Gr‐1⁺ myeloid cells.
Kaitlyn M. Landreth, Dylan D. Thomas, Remi Nohoesu, Angisha Basnet, F. Heath Damron, Mary Garland‐Kledzik, Emel Sen Kilic, Tracy W. Liu   +7 more
wiley   +1 more source

Spatial accessibility of emergency medical services under inclement weather: a case study in Beijing, China [PDF]

Natural Hazards and Earth System Sciences
The accessibility of emergency medical services (EMSs) is not only determined by the distribution of emergency medical facilities but is also influenced by weather conditions.
Y. Zhang, K. Liu, K. Liu, X. Ni, X. Ni, M. Wang, M. Wang, J. Zheng, M. Liu, D. Yu   +9 more
doaj   +1 more source