Results 81 to 90 of about 2,340,109 (293)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Vapor pressure deficit shapes the distributions of carbon use efficiency across Siberia

Carbon Balance and Management
As a key indicator of terrestrial carbon cycle, carbon use efficiency (CUE) represents the efficiency of carbon fixation and carbon allocation strategy, shaping ecosystem function and services.
Kailin Gao, Qian Zhang, Mingzhu He
doaj   +1 more source

Deep Learning Models for Hazard-Damaged Building Detection Using Remote Sensing Datasets: A Comprehensive Review

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Building collapse is a leading cause of casualties and economic losses during disasters. Accurate and timely assessment of building damage is critical for effective emergency response and recovery efforts.
Lili Wang, Jidong Wu, Youtian Yang, Rumei Tang, Ru Ya   +4 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Integrating LULC and ecosystem services into multi-scale ecological security assessment and management zoning in fragile mountainous regions

Environmental and Sustainability Indicators
Ecological security (ES) is a crucial indicator of regional ecosystem health and integrity, serving as a fundamental basis for formulating sustainable ecological management strategies, particularly in ecologically fragile regions.
Yizhen Wang, Siyuan Li, Shuyi Shi, Heng Yang, Shiliang Liu, Jun Tao   +5 more
doaj   +1 more source

Measuring systemic risk [PDF]

We present a simple model of systemic risk and show how each financial institution’s contribution to systemic risk can be measured and priced.
Lasse H. Pedersen, Matthew Richardson, Thomas Philippon, Viral V. Acharya   +3 more
core  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Advances in complex climate change risk assessment for adaptation

npj Climate Action
Recent advances in climate change risk assessment and management and their application across cities, coastal zones, and finance highlight promising opportunities for near-term action to better govern complex climate change risk and advance adaptation ...
Nicholas P. Simpson, Edward Sparkes, Marleen de Ruiter, Robert Šakić Trogrlić, Marlon Vieira Passos, Julius Schlumberger, Judy Lawrence, Reinhard Mechler, Stefan Hochrainer-Stigler   +8 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Photovoltaic installations are extensively deployed in areas at risk of extremely low production

Communications Earth & Environment
Photovoltaic (PV) installations have rapidly and extensively been deployed worldwide as a promising alternative renewable energy source. However, weather anomalies could expose them to challenges in supply security by causing very low power production ...
Qianzhi Wang, Kai Liu, Wei Xie, Tariq Ali, Jinshan Wu, Ming Wang   +5 more
doaj   +1 more source