Results 81 to 90 of about 1,292,257 (266)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Deep Learning Models for Hazard-Damaged Building Detection Using Remote Sensing Datasets: A Comprehensive Review

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Building collapse is a leading cause of casualties and economic losses during disasters. Accurate and timely assessment of building damage is critical for effective emergency response and recovery efforts.
Lili Wang, Jidong Wu, Youtian Yang, Rumei Tang, Ru Ya   +4 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Vapor pressure deficit shapes the distributions of carbon use efficiency across Siberia

Carbon Balance and Management
As a key indicator of terrestrial carbon cycle, carbon use efficiency (CUE) represents the efficiency of carbon fixation and carbon allocation strategy, shaping ecosystem function and services.
Kailin Gao, Qian Zhang, Mingzhu He
doaj   +1 more source

Integrating LULC and ecosystem services into multi-scale ecological security assessment and management zoning in fragile mountainous regions

Environmental and Sustainability Indicators
Ecological security (ES) is a crucial indicator of regional ecosystem health and integrity, serving as a fundamental basis for formulating sustainable ecological management strategies, particularly in ecologically fragile regions.
Yizhen Wang, Siyuan Li, Shuyi Shi, Heng Yang, Shiliang Liu, Jun Tao   +5 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Advances in complex climate change risk assessment for adaptation

npj Climate Action
Recent advances in climate change risk assessment and management and their application across cities, coastal zones, and finance highlight promising opportunities for near-term action to better govern complex climate change risk and advance adaptation ...
Nicholas P. Simpson, Edward Sparkes, Marleen de Ruiter, Robert Šakić Trogrlić, Marlon Vieira Passos, Julius Schlumberger, Judy Lawrence, Reinhard Mechler, Stefan Hochrainer-Stigler   +8 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Photovoltaic installations are extensively deployed in areas at risk of extremely low production

Communications Earth & Environment
Photovoltaic (PV) installations have rapidly and extensively been deployed worldwide as a promising alternative renewable energy source. However, weather anomalies could expose them to challenges in supply security by causing very low power production ...
Qianzhi Wang, Kai Liu, Wei Xie, Tariq Ali, Jinshan Wu, Ming Wang   +5 more
doaj   +1 more source