Results 91 to 100 of about 1,400,728 (314)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The threat of systemic risk in banking: evidence for Europe [PDF]

This paper attempts to answer the question whether the threat of systemic risk in banking exists only on a national or on a European level. Following De Nicolo and Kwast (2001), mean rolling-window correlations between bank stock returns are used as a ...
Schüler, Martin
core  

Vapor pressure deficit shapes the distributions of carbon use efficiency across Siberia

Carbon Balance and Management
As a key indicator of terrestrial carbon cycle, carbon use efficiency (CUE) represents the efficiency of carbon fixation and carbon allocation strategy, shaping ecosystem function and services.
Kailin Gao, Qian Zhang, Mingzhu He
doaj   +1 more source

Integrating LULC and ecosystem services into multi-scale ecological security assessment and management zoning in fragile mountainous regions

Environmental and Sustainability Indicators
Ecological security (ES) is a crucial indicator of regional ecosystem health and integrity, serving as a fundamental basis for formulating sustainable ecological management strategies, particularly in ecologically fragile regions.
Yizhen Wang, Siyuan Li, Shuyi Shi, Heng Yang, Shiliang Liu, Jun Tao   +5 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Systemic risk across sectors; Are banks different? [PDF]

This research compares systemic risk in the banking sector, the insurance sector, the construction sector, and the food sector. To measure systemic risk, we use extreme negative returns in stock market data for a time-varying panel of the 20 largest U.S.
Sander Muns, Michiel Bijlsma
core  

Systemic risk in the financial sector: what can we learn from option markets? : [version 12 july 2013] [PDF]

, 2013
In this paper, we propose a novel approach on how to estimate systemic risk and identify its key determinants. For all US financial companies with publicly traded equity options, we extract their option-implied value-at-risks (VaRs) and measure the ...
Kraft, Holger, Schmidt, Alexander
core   +1 more source

Advances in complex climate change risk assessment for adaptation

npj Climate Action
Recent advances in climate change risk assessment and management and their application across cities, coastal zones, and finance highlight promising opportunities for near-term action to better govern complex climate change risk and advance adaptation ...
Nicholas P. Simpson, Edward Sparkes, Marleen de Ruiter, Robert Šakić Trogrlić, Marlon Vieira Passos, Julius Schlumberger, Judy Lawrence, Reinhard Mechler, Stefan Hochrainer-Stigler   +8 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Systemic Risk in European Banking: Evidence from Bivariate GARCH Models [PDF]

This paper attempts to assess the Europe-wide systemic risk in banking. We employ a bivariate GARCH model to estimate conditional correlations between European bank stock indices.
Schüler, Martin, Schröder, Michael
core