Results 91 to 100 of about 33,761 (217)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Intensifying Climate Extremes Over the Tibetan Plateau: Past–Future Changes and Implications for Railway Infrastructure

open access: yesEarth and Space Science
Climate extremes over the Tibetan Plateau (TP) are intensifying and can threaten high‐altitude railways by altering permafrost stability, freeze–thaw regimes, drainage pressure, and hydro‐geomorphic hazards, yet their evolution for railways remains ...
Bohao Li   +9 more
doaj   +1 more source

Estimating Global Wheat Yields at 4 km Resolution during 1982–2020 by a Spatiotemporal Transferable Method

open access: yesRemote Sensing
Reliable and spatially explicit information on global crop yield has paramount implications for food security and agricultural sustainability. However, most previous yield estimates are either coarse-resolution in both space and time or are based on ...
Zhao Zhang   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Exposure of Global Rail and Road Infrastructures in Future Record‐Breaking Climate Extremes

open access: yesEarth's Future
Transport infrastructures built on historical experience are expected to face multiple threats under climate change, especially the continuous interruptive losses and additional maintenance costs caused by more intense or frequent record‐breaking extreme
Qianzhi Wang   +4 more
doaj   +1 more source

Divergent responses of forest canopy height to environmental conditions across China

open access: yesEcological Indicators
As major components of terrestrial ecosystems, forest ecosystems play an important role in sequestering carbon and hence mitigating climate change. Canopy height is a crucial factor characterizing the structure and function of forest ecosystems, yet the ...
Xiang Pan   +5 more
doaj   +1 more source

Systemic risk and the European Systemic Risk Board [PDF]

open access: yes, 2009
Financial crises are often characterised by a few financial institutions \ud failing, followed by a cascade of collapses. Economists are not good at \ud predicting which shocks will trigger an initial collapse. Thus, an early \ud warning system might be better focused on measuring systemic risk, or \ud the vulnerability of the financial system to the ...
openaire  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

A Novel Flood Risk Analysis Framework Based on Earth Observation Data to Retrieve Historical Inundations and Future Scenarios

open access: yesRemote Sensing
Global warming is exacerbating flood hazards, making the robustness of flood risk management a critical issue. Without considering future scenarios, flood risk analysis built only on historical knowledge may not adequately address the coming challenges ...
Kezhen Yao   +9 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

open access: yesFEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo   +4 more
wiley   +1 more source

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