Results 81 to 90 of about 2,326,154 (344)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Vapor pressure deficit shapes the distributions of carbon use efficiency across Siberia

Carbon Balance and Management
As a key indicator of terrestrial carbon cycle, carbon use efficiency (CUE) represents the efficiency of carbon fixation and carbon allocation strategy, shaping ecosystem function and services.
Kailin Gao, Qian Zhang, Mingzhu He
doaj   +1 more source

Deep Learning Models for Hazard-Damaged Building Detection Using Remote Sensing Datasets: A Comprehensive Review

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Building collapse is a leading cause of casualties and economic losses during disasters. Accurate and timely assessment of building damage is critical for effective emergency response and recovery efforts.
Lili Wang, Jidong Wu, Youtian Yang, Rumei Tang, Ru Ya   +4 more
doaj   +1 more source

Psychiatric and Systemic Risk Factors for Dry Eye Disease in Adult Korean Population Aged 40 Years or Older: Korea National Health and Nutrition Examination Survey 2017-2018 (KNHANES VII) [PDF]

, 2023
Joon Young Hyon, Jae Yeon Lee, Joon Young Hyon, Sang Beom Han   +3 more
openalex   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Advances in complex climate change risk assessment for adaptation

npj Climate Action
Recent advances in climate change risk assessment and management and their application across cities, coastal zones, and finance highlight promising opportunities for near-term action to better govern complex climate change risk and advance adaptation ...
Nicholas P. Simpson, Edward Sparkes, Marleen de Ruiter, Robert Šakić Trogrlić, Marlon Vieira Passos, Julius Schlumberger, Judy Lawrence, Reinhard Mechler, Stefan Hochrainer-Stigler   +8 more
doaj   +1 more source

Dynamic changes in soil erosion and challenges to grain productivity in the black soil region of Northeast China

Ecological Indicators
Soil erosion presents a significant obstacle to food and ecosystem security. This study combined multi-source data to construct a soil erosion model and challenges to grain productivity in the black soil region of Northeast China.
Jiawang Zhang, Ming Wang, Kai Liu, Zhan’ao Zhao   +3 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source