Results 81 to 90 of about 41,948 (242)

Pathogenesis of Scleroderma (Systemic Sclerosis)

Journal of Investigative Dermatology, 1982
Increasing interest in the vascular features of scleroderma has led to the hypothesis that the blood vessel is the major target tissue and that the endothelial cell is the principal cell target. Useful observations stemming from the vascular hypothesis include the use of microvascular abnormalities in the early detection of the patient destined to ...
openaire   +2 more sources

GLP‐1 Receptor Agonists and Endoscopy: Understanding Gastric Stasis, Aspiration Risk, and Contemporary Peri‐Procedural Guidance

Chronic Diseases and Translational Medicine, EarlyView.
Pharmacological mechanisms and physiologic effects of GLP‐1 receptor agonists relevant to peri‐endoscopic risk. ABSTRACT The global increase in obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction‐associated steatotic liver disease (MASLD) has led to a higher use of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) among patients ...
Junaid Beig, Jason Ta, Sophie Jones, Emily Scott, Khalid Sofi, Frances Osler, Marije Jansen, Puneet Chhabra   +7 more
wiley   +1 more source

MicroRNAs in fibrosis: opportunities and challenges [PDF]

, 2016
MicroRNAs (miRNAs) are small, non-coding RNAs that mediate mRNA cleavage, translational repression or mRNA destabilisation and are around 22-25 nucleotides in length via partial complementary binding to the 3' untranslated region in target transcripts ...
O'Reilly, Steven, Steven O’Reilly
core   +1 more source

Association of Childhood Acute Leukemia With Autoimmune Diseases

International Journal of Cancer, EarlyView.
A possible link exists between various pediatric autoimmune diseases (AIDs) and increased risk of childhood leukemia. Although immune dysregulation is a key feature of these conditions, the connection between them remains unclear. In this study, using cancer registry data in Finland, the authors examined associations between AIDs and childhood acute ...
Ida Pellikka, Julia Ventelä, Anssi Auvinen, Olli Lohi, Atte Nikkilä   +4 more
wiley   +1 more source

Gender differences in juvenile systemic sclerosis patients: Results from the international juvenile scleroderma inception cohort

, 2022
Objective: To compare organ involvement and disease severity between male and female patients with juvenile onset systemic sclerosis. Methods: Demographics, organ involvement, laboratory evaluation, patient-reported outcomes and physician assessment ...
Adrovic, Amra, Torok, Kathryn S., Vasquez-Canizares, Natalia, Kostik, Mikhail, Helmus, Nicola,, Bica, Blanca, Nielsen, Susan, Marrani, Edoardo, Appenzeller, Simone,, Jordi Anton, Avcin, Tadej, Daniela Kaiser, Ana Paula Sakamoto, Appenzeller, Simone, Helmus, Nicola, Johnson, Sindhu R, Sztajnbok, Flavio, Despina Eleftheriou, Feldman, Brian M., Walter-Alberto Sifuentes-Giraldo, Lehman, Thomas,, Ozgur Kasapcopur, Marrani, Edoardo,, Opsahl Hetlevik, Siri,, Anjali Patwardhan, Nemcova, Dana, Jürgen Brunner, Brian M Feldman, Horneff, Gerd,, Alexeeva, Ekaterina,, Sawhney, Sujata,, Valda Stanevicha, Simone Appenzeller, Eleftheriou, Despina,, Minden, Kirsten, Battagliotti, Cristina,, Tilmann Kallinich, Janarthanan, Mahesh, Uziel, Yosef, Kallinich, Tilmann, Ivan Foeldvari, Nicola Helmus, Gerd Horneff, Farzana Nuruzzaman, Feldman, Brian M.,, Costa-Reis, Patricia, Feldman, Brian M, Dana Nemcova, Sakamoto, Ana Paula,, Anton, Jordi,, Stanevicha, Valda,, Janarthanan, Mahesh,, Klotsche, Jens,, Kostik, Mikhail,, Katsicas, Maria, Nuruzzaman, Farzana,, Brunner, J. rgen, Avcin, Tadej,, Thomas Lehman, Dieneke Schonenberg-Meinema, Mikhail Kostik, Khubchandani, Raju,, Berntson, Lillemor,, Kaiser, Daniela,, Terreri, Maria Teresa,, Patwardhan, Anjali, Siri Opsahl Hetlevik, Costa-Reis, Patricia,, Adrovic, Amra,, Maria Jose Santos, Patwardhan, Anjali,, Dragana Lazarevic, Berntson, Lillemor, Amra Adrovic, Harel, Liora,, Sifuentes-Giraldo, Walter-Alberto, Santos, Maria Jose, Lazarevic, Dragana,, Smith, Vanessa, Blanca Bica, Vasquez-Canizares, Natalia,, Opsahl Hetlevik, Siri, Yosef Uziel, Susan Nielsen, Kathryn S Torok, Kallinich, Tilmann,, Patricia Costa-Reis, Sindhu R Johnson, Cimaz, Rolando,, Sujata Sawhney, Kasapcopur, Ozgur, Flavio Sztajnbok, Vanessa Smith, Harel, Liora, Kasapcopur, Ozgur,, Santos, Maria Jose,, Maria Katsicas, Rolando Cimaz, Sifuentes-Giraldo, Walter-Alberto,, Monika Moll, Johnson, Sindhu R., Tadej Avcin, Khubchandani, Raju, Klotsche, Jens, Horneff, Gerd, Lehman, Thomas, Maria Teresa Terreri, Mahesh Janarthanan, Moll, Monika,, Bica, Blanca,, Kaiser, Daniela, Cristina Battagliotti, Stanevicha, Valda, Kirsten Minden, Johnson, Sindhu R.,, Raju Khubchandani, Brunner, Jürgen,, Sakamoto, Ana Paula, Nielsen, Susan,, Sawhney, Sujata, Katsicas, Maria,, Anton, Jordi, Jens Klotsche, Torok, Kathryn S, Terreri, Maria Teresa, Liora Harel, Nemcova, Dana,, Lazarevic, Dragana, Edoardo Marrani, Cimaz, Rolando, Schonenberg-Meinema, Dieneke, Eleftheriou, Despina, Sztajnbok, Flavio,, Alexeeva, Ekaterina, Lillemor Berntson, Ekaterina Alexeeva, Smith, Vanessa,, Foeldvari, Ivan,, Minden, Kirsten,, Schonenberg-Meinema, Dieneke,, Moll, Monika, Brunner, Jürgen, Nuruzzaman, Farzana, Natalia Vasquez-Canizares, Foeldvari, Ivan, Battagliotti, Cristina   +145 more
core   +1 more source

Control of Fibrosis in Systemic Scleroderma.

Journal of Investigative Dermatology, 1993
Scleroderma is characterized by an excessive deposition of collagen in all involved organs. This is due to an overproduction of extracellular matrix (ECM) molecules following induction of gene expression, whereas there is no evidence that the composition of the connective tissue matrix is altered.
Mauch, Cornelia, Eckes, Beate, Hunzelmann, Nicolas, Oono, Takashi, Kozlowska, Ewa, Krieg, Thomas   +5 more
openaire   +2 more sources

Characterization of Pulmonary Functional Abnormalities in Systemic Sclerosis Using Xenon MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Xenon MRI is increasingly used to evaluate patients with interstitial lung disease (ILD) and pulmonary hypertension (PH), both of which are common manifestations of systemic sclerosis (SSc). As such, Xe‐MRI may be suited to interrogate lung function impairment in SSc.
Dawson Shaver, Steven Haworth, Evan Graumann, Bradie Frizzell, David H. Lee, Jiwoong Choi, Chase S. Hall, Scott M. Matson, Mark Hamblin, Mario Castro, Paul S. Schmidt, Peter J. Niedbalski   +11 more
wiley   +1 more source

IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics

, 2016
Systemic sclerosis is an autoimmune connective tissue disease in which T cells play a prominent role. We and others have previously demonstrated a role for T cell-derived IL-13 in mediating the induction of collagen in dermal fibroblasts and that ...
van Laar, Jacob, Van Laar, Jacob M., O'Reilly, Steven, Fullard, Nicola, Ciechomska, Marzena, Przyborski, Stefan, van Laar, J.M., O’Reilly, S., Fullard, N., Przyborski, S., Ciechomska, M.   +10 more
core   +1 more source

Systemic Sclerosis Sine Scleroderma

, 2020
Scleroderma and systemic sclerosis are autoimmune phenomena that can cause progressive and permanent damage to the organs of the human body. Rarely, the only manifestation of systemic sclerosis is severe hypertension with renal failure, a subset known as
Lugo, Adrian, Ramamurthy, Guruswamy, Cappiello, Andrew   +2 more
core   +1 more source

Assessment of Treatment Response in Patients With Scleromyxedema by the Double Modified Rodnan Skin Score

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Scleromyxedema (SMX) is a cutaneous mucinosis characterised by an abnormal accumulation of mucin in the skin and limited treatment options. Assessment of therapy response during treatment is challenging. Objectives Patients with SMX receiving high‐dose intravenous IVIg therapy were included to assess validity of the double modified ...
Julia K. Winkler, Alexander H. Enk
wiley   +1 more source