Results 61 to 70 of about 55,246 (249)

Formyl Peptide Receptor 2 Activation Ameliorates Dermal Fibrosis and Inflammation in Bleomycin-Induced Scleroderma

Frontiers in Immunology, 2019
Systemic sclerosis is a profibrotic autoimmune disease mediated by the dysregulation of extracellular matrix synthesis. Formyl peptide receptor 2 (Fpr2) is a G protein-coupled receptor that modulates inflammation and host defense by regulating the ...
Gyu Tae Park, Yang Woo Kwon, Tae Wook Lee, Seong Gyu Kwon, Hyun-Chang Ko, Moon Bum Kim, Jae Ho Kim, Jae Ho Kim   +7 more
doaj   +1 more source

Value of systolic pulmonary arterial pressure as a prognostic factor of death in the systemic sclerosis EUSTAR population. [PDF]

, 2015
The aim of this study was to assess the prognostic value of systolic pulmonary artery pressure (sPAP) estimated by echocardiography in the multinational European League Against Rheumatism Scleroderma Trial and Research (EUSTAR) cohort.Data for patients ...
C. M., Mihai, C. P., Denton, D., Launay, E., Hachulla, G., Cuomo, G., Riemekasten, M. R., Pozzi, M., Matucci Cerinic, M., Sarraco, O., Distler, on behalf of the EUSTAR co, Workers, P. E., Carreira, P., Airò, P., Caramaschi, P., Clerson, Riccieri, Valeria, Rosato, Edoardo, S., Rednic, S., Ullman, S., Zeni, U. A., Walker, U., Müller Ladner, V., Smith, Y., Allanore   +23 more
core   +1 more source

Discordance Between Patient and Physician Global Assessments in Early Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective This study aims to identify factors associated with patient global assessment (PtGA) and physician global assessment (PhGA) and discordance between them in systemic sclerosis (SSc). Methods Data from adults with early SSc (<5 years) from the Collaborative National Quality and Efficacy Registry were included.
Ellen Romich, Alexis Ogdie, Alisa Stephens Shields, Peter A. Merkel, Shervin Assassi, Elana J. Bernstein, Andreea Bujor, Flavia V. Castelino, Lorinda Chung, Luke B. Evnin, Tracy M. Frech, Jessica K. Gordon, Melissa Griffith, Faye N. Hant, Monica L. Harding, Laura K. Hummers, Dinesh Khanna, Kimberly S. Lakin, Dorota J. Lebiedz‐Odrobina, Yiming Luo, Ashima Makol, Maureen D. Mayes, Zsuzsanna H. McMahan, Jerry Molitor, Duncan F. Moore, Julie Paik, Carrie Richardson, Brian Skaug, Ami A. Shah, Ankoor Shah, Virginia Steen, John M. VanBuren, Elizabeth R. Volkmann, Carleigh Zahn, Nora Sandorfi, for the CONQUER Investigators   +35 more
wiley   +1 more source

SCLERODERMA NEPHROPATHY: UNSOLVED PROBLEMS

Juvenis Scientia, 2021
Kidney injury is a common pathology in the group of patients with systemic sclerosis. At least half of the patients show histological signs of it. Acute condition is known as scleroderma renal crisis.
I. E. Bulavko, E. V. Timofeev, K. J. U. Alkak, V. A. Isakov   +3 more
doaj   +1 more source

Molecular mimicry, genetic homology, and gene sharing proteomic “molecular fingerprints” using an EBV (Epstein-Barr virus)-derived microarray as a potential diagnostic method in autoimmune disease [PDF]

, 2018
EBV (Epstein-Barr Virus) and other human DNA viruses are associated with autoimmune syndromes in epidemiologic studies. In this work, immunoglobulin G response to EBV-encoded proteins which share regions with human immune response proteins from the human
Alessandra Farina, Giuseppina, Dreyfus, David H., FARINA, Antonella   +2 more
core   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Immunologic and nonimmunologic sclerodermal skin conditions - review

Frontiers in Immunology, 2023
Scleroderma-like cutaneous lesions have been found in many pathological conditions and they have the clinical appearance of sclerotic or scleroatrophic lesions.
Carmen Bobeica, Elena Niculet, Elena Niculet, Mihaela Craescu, Mihaela Craescu, Elena-Laura Parapiru, Andreea Mioara Corduneanu-Luca, Mihaela Debita, Ana Maria Pelin, Carmen Tiutiuca, Claudiu Ionut Vasile, Alin Codrut Nicolescu, Magdalena Miulescu, Gabriela Balan, Gabriela Balan, Alin Laurentiu Tatu, Alin Laurentiu Tatu, Alin Laurentiu Tatu   +17 more
doaj   +1 more source

In systemic sclerosis skin perfusion of hands is reduced and may predict the occurrence of new digital ulcers [PDF]

, 2017
Systemic sclerosis (SSc) patients are at high risk for the development of ischemic digital ulcers (DUs). The aim of this study was to assess in SSc patients a correlation between skin perfusion evaluated by LDPI and DUs and to evaluate the prognostic ...
Barbano, Biagio, Barilaro, Giuseppe, Gasperini, Maria Ludovica, Gigante, Antonietta, Marra, Alessandro Maria, Quarta, Silvia, Rosato, Edoardo   +6 more
core   +1 more source

A Cooperative Release of Mitochondrial DNA From Platelets and Neutrophils Drives an Interferon Signature in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the role of circulating DNA in systemic sclerosis (SSc) and the cellular mechanisms governing its release.
Stavros Giaglis, André N. Tiaden, Simone Häner‐Massimi, Diego Kyburz, Cedric André, Anton Glück, Enrico Ferrero, Stuart Hawtin, Tobias Junt, Ulrich A. Walker   +9 more
wiley   +1 more source

Optimal management strategies for paediatric morphea – insights from a case series

Pediatria Polska
Juvenile localized scleroderma, or morphea, is a rare chronic inflammatory disease primarily affecting the skin and subcutaneous tissue. Treatment options for paediatric cases are diverse, with a lack of standardised guidelines.
Kinga Łagosz, Natalia Bień, Justyna Ceryn, Paulina Barsińska, Dorota Sobolewska-Sztychny, Joanna Narbutt, Aleksandra Lesiak   +6 more
doaj   +1 more source