Results 51 to 60 of about 41,948 (242)

Docetaxel-Induced Systemic Sclerosis with Internal Organ Involvement Masquerading as Congestive Heart Failure

Case Reports in Immunology, 2017
Systemic sclerosis, or scleroderma, is a complex medical disorder characterized by limited or diffuse skin thickening with frequent involvement of internal organs such as lungs, gastrointestinal tract, or kidneys.
Bumsoo Park, Raghavendra C. Vemulapalli, Amit Gupta, Maria E. Shreve, Della A. Rees   +4 more
doaj   +1 more source

Formyl Peptide Receptor 2 Activation Ameliorates Dermal Fibrosis and Inflammation in Bleomycin-Induced Scleroderma

Frontiers in Immunology, 2019
Systemic sclerosis is a profibrotic autoimmune disease mediated by the dysregulation of extracellular matrix synthesis. Formyl peptide receptor 2 (Fpr2) is a G protein-coupled receptor that modulates inflammation and host defense by regulating the ...
Gyu Tae Park, Yang Woo Kwon, Tae Wook Lee, Seong Gyu Kwon, Hyun-Chang Ko, Moon Bum Kim, Jae Ho Kim, Jae Ho Kim   +7 more
doaj   +1 more source

Discordance Between Patient and Physician Global Assessments in Early Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective This study aims to identify factors associated with patient global assessment (PtGA) and physician global assessment (PhGA) and discordance between them in systemic sclerosis (SSc). Methods Data from adults with early SSc (<5 years) from the Collaborative National Quality and Efficacy Registry were included.
Ellen Romich, Alexis Ogdie, Alisa Stephens Shields, Peter A. Merkel, Shervin Assassi, Elana J. Bernstein, Andreea Bujor, Flavia V. Castelino, Lorinda Chung, Luke B. Evnin, Tracy M. Frech, Jessica K. Gordon, Melissa Griffith, Faye N. Hant, Monica L. Harding, Laura K. Hummers, Dinesh Khanna, Kimberly S. Lakin, Dorota J. Lebiedz‐Odrobina, Yiming Luo, Ashima Makol, Maureen D. Mayes, Zsuzsanna H. McMahan, Jerry Molitor, Duncan F. Moore, Julie Paik, Carrie Richardson, Brian Skaug, Ami A. Shah, Ankoor Shah, Virginia Steen, John M. VanBuren, Elizabeth R. Volkmann, Carleigh Zahn, Nora Sandorfi, for the CONQUER Investigators   +35 more
wiley   +1 more source

Intravenous iloprost in the combination therapy of vascular disorders in patients with systemic connective tissue diseases

Современная ревматология, 2013
Systemic connective tissue diseases, systemic scleroderma in particular, constitute a group of diseases in which vascular disorders underlying diverse clinical manifestations are one of the pathogenetic components.
Aleksandr Vitalyevich Volkov, N N Yudkina   +1 more
doaj   +1 more source

Immunosuppressive Drug Use in Limited Systemic Sclerosis: An International Survey

Arthritis Care &Research, EarlyView.
Objective Current guidelines recommend immunosuppressive treatment for diffuse cutaneous systemic sclerosis but are less clear on their use in limited cutaneous systemic sclerosis (lcSSc) in the absence of internal organ complications. We conducted an international survey to understand current immunosuppressive drug prescribing patterns in lcSSc ...
Sabrina Hoa, Yicheng Mu, Marie Hudson, Janet Pope   +3 more
wiley   +1 more source

Treatment Algorithms for Systemic Sclerosis According to Experts

, 2018
OBJECTIVE: There is a lack of agreement regarding treatment for many aspects of systemic sclerosis (SSc). We undertook this study to generate SSc treatment algorithms endorsed by a high percentage of SSc experts.
Walker KM, Pope JE, 1. Fernández-Codina A, Murdaca G, Scleroderma Algorithm Group   +4 more
core   +2 more sources

SCLERODERMA NEPHROPATHY: UNSOLVED PROBLEMS

Juvenis Scientia, 2021
Kidney injury is a common pathology in the group of patients with systemic sclerosis. At least half of the patients show histological signs of it. Acute condition is known as scleroderma renal crisis.
I. E. Bulavko, E. V. Timofeev, K. J. U. Alkak, V. A. Isakov   +3 more
doaj   +1 more source

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Arthritis Care &Research, EarlyView.
Objective The objective is to describe and compare demographic, clinical, and serological characteristics of patients with systemic sclerosis (SSc) according to ethnic background. Methods Participants enrolled in the Canadian Scleroderma Research Group cohort who self‐identified to a single ethnicity group were included.
Danick Goulet, Camille Guertin, Maggie Larché, Isabelle Ferdinand, Marie Hudson, May Y. Choi, Mohammed Osman, Janet Pope, Carter Thorne, Murray Baron, Sasha Bernatsky, Sabrina Hoa   +11 more
wiley   +1 more source

Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts

, 2009
Background: Fibrosis, the excessive deposition of scar tissue by fibroblasts, is one of the largest groups of diseases for which there is no therapy. Fibroblasts from lesional areas of scleroderma patients possess elevated abilities to contract matrix ...
Christopher P Denton, Abraham, DJ, Denton, CP, Mark Eastwood, Sonali Sonnylal, Shi-Wen, X., Liu Shangxi, Leask, A., Abraham David J., Liu, SX, Shi-wen, X, Denton, C.P., Shangxi Liu, Sonnylal, S, Abraham, D.J., David J Abraham, Liu, S., Andrew Leask, Shi-wen Xu, Denton Christopher P., Eastwood Mark, Eastwood, M, Leask, A, Eastwood, M., Sonnylal Sonali, Leask Andrew, Sonnylal, S.   +26 more
core   +1 more source

Optimal management strategies for paediatric morphea – insights from a case series

Pediatria Polska
Juvenile localized scleroderma, or morphea, is a rare chronic inflammatory disease primarily affecting the skin and subcutaneous tissue. Treatment options for paediatric cases are diverse, with a lack of standardised guidelines.
Kinga Łagosz, Natalia Bień, Justyna Ceryn, Paulina Barsińska, Dorota Sobolewska-Sztychny, Joanna Narbutt, Aleksandra Lesiak   +6 more
doaj   +1 more source