Results 91 to 100 of about 2,931,663 (352)

Decreased levels of autoantibody against histone deacetylase 3 in patients with systemic sclerosis. [PDF]

, 2009
Systemic sclerosis (SSc) is characterized by immunological abnormalities, especially the production of autoantibodies against various cellular components.
Ogawa, Fumihide, Fujimoto, Manabu, Kuwatsuka, Yutaka, Iwata, Yohei, Muroi, Eiji, Hara, Toshihide, Komura, Kazuhiro, Hasegawa, Minoru, Sato, Shinichi, Takenaka, Motoi, Shimizu, Kazuhiro   +10 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Aortic Regurgitation in a Patient with Rheumatoid Arthritis/Systemic Lupus Erythematosus Overlap Syndrome (Rhupus): Case Report and Review of Literature

Journal of Cardiovascular Development and Disease
Background/Objectives: Cardiovascular diseases (CVDs), including valvular heart disease (VHD), remain the leading cause of morbidity and mortality in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
Mislav Radić, Hana Đogaš, Tina Bečić, Petra Šimac, Ivana Jukić, Josipa Radić, Damir Fabijanić   +6 more
doaj   +1 more source

Predictors of progression in systemic sclerosis patients with interstitial lung disease

European Respiratory Journal, 2020
Systemic sclerosis (SSc) is a systemic autoimmune disease affecting multiple organ systems, including the lungs. Interstitial lung disease (ILD) is the leading cause of death in SSc.
O. Distler, S. Assassi, V. Cottin, M. Cutolo, S. Danoff, C. Denton, J. Distler, A. Hoffmann-Vold, S. Johnson, U. Müller-Ladner, V. Smith, E. Volkmann, T. Maher   +12 more
semanticscholar   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Systemic sclerosis – multidisciplinary disease: clinical features and treatment

Rheumatology, 2019
Systemic sclerosis is a chronic autoimmune disease of still not fully understood pathogenesis. Fibrosis, vascular wall damage, and disturbances of innate and acquired immune responses with autoantibody production are prominent features.
Piotr Sobolewski, Maria Maślińska, Marta Wieczorek, Zuzanna Łagun, Aleksandra Malewska, Marek Roszkiewicz, Raman Nitskovich, Elżbieta Szymańska, Irena Walecka   +8 more
doaj   +1 more source

Using Autoantibodies and Cutaneous Subset to Develop Outcome‐Based Disease Classification in Systemic Sclerosis

Arthritis & Rheumatology, 2020
To describe the associations between autoantibodies, clinical presentation, and outcomes among patients with systemic sclerosis (SSc) in order to develop a novel SSc classification scheme that would incorporate both antibodies and the cutaneous disease ...
S. Nihtyanova, A. Sarı, J. Harvey, A. Leslie, E. Derrett-Smith, C. Fonseca, V. Ong, C. Denton   +7 more
semanticscholar   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Stubborn rectal prolapse in systemic sclerosis [PDF]

, 2017
Systemic sclerosis (SSc) is an autoimmune connective tissue disorder. Anorectal involvement might typically cause fecal incontinence and rarely rectal prolapse.
Ina Kötter, Uwe Wollina, Gero Puhl, Sven Petersen, Alexander Tobisch   +4 more
core   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source