Results 71 to 80 of about 2,931,663 (352)

SYSTEMIC SCLEROSIS AND OSTEOPOROSIS

Alʹmanah Kliničeskoj Mediciny, 2016
Systemic sclerosis is an autoimmune inflammatory disease of connective tissue with multi-syndrome clinical manifestations. Skeletal damage is considered to be one of significant contributors to the quality of life of these patients.
R. T. Alekperov, N. V. Toroptsova
doaj   +1 more source

CD19-targeting CAR T-cell therapy in patients with diffuse systemic sclerosis: a case series.

The Lancet Rheumatology
BACKGROUND CD19-targeting chimeric antigen receptor (CAR) T-cell therapy has shown remarkable outcomes in patients with systemic lupus erythematosus. The effects of CD19-targeting CAR T cells on organ manifestations in patients with systemic sclerosis ...
J. Auth, Fabian Müller, S. Völkl, Nadine Bayerl, Jörg H. W. Distler, Carlo Tur, M. Raimondo, Sara Chenguiti Fakhouri, A. Atzinger, B. Coppers, Markus Eckstein, A. Liphardt, T. Bäuerle, K. Tascilar, M. Aigner, S. Kretschmann, A. Wirsching, J. Taubmann, Melanie Hagen, A. Györfi, S. Kharboutli, T. Krickau, C. Dees, Silvia Spörl, T. Rothe, Thomas Harrer, A. Bozec, R. Grieshaber-Bouyer, Florian Fuchs, Torsten Kuwert, C. Berking, R. E. Horch, Michael Uder, A. Mackensen, G. Schett, Christina Bergmann   +35 more
semanticscholar   +1 more source

Progressive systemic sclerosis in a child

Indian Journal of Dermatology, 2013
Systemic sclerosis is a clinically heterogeneous systemic disease affecting the connective tissues of skin, walls of blood vessels and internal organs like lung, heart and kidneys. Systemic sclerosis is very unusual in pediatric population.
Arun K De, Kallol Das, Archan Sil, Swarnali Joardar   +3 more
doaj   +1 more source

Osteopetrosis in a Patient of Systemic Sclerosis Sine Scleroderma: A Rare Association

Indian Journal of Radiology and Imaging, 2021
Systemic sclerosis is a connective tissue disorder of unknown etiology. Although it is a multisystemic disorder, skin thickening is considered as a hallmark of the disease.
Saroj K. Pati, Praveen Raja, Ajoy K. Behera, T.G. Ranganath, Narendra K. Bodhey   +4 more
doaj   +1 more source

Application of blinatumomab, a bispecific anti-CD3/CD19 T-cell engager, in treating severe systemic sclerosis: A case study.

European Journal of Cancer
Systemic sclerosis, a severe inflammatory autoimmune disease, shares a common thread with cancer through the underlying mechanism of inflammation. This inflammatory milieu not only drives the immune dysregulation characteristic of autoimmune diseases but
M. Subklewe, Giulia Magno, C. Gebhardt, V. Bücklein, F. Szelinski, Hector Arévalo, Gerulf Hänel, T. Dörner, G. Zugmaier, M. V. von Bergwelt-Baildon, A. Skapenko, Hendrik Schulze-Koops   +11 more
semanticscholar   +1 more source

Factors Associated with Systemic Lupus Erythematosus-Associated Interstitial Lung Disease and Clinical Outcomes: A Systematic Review and Meta-Analysis

Medicina
Background and Objectives: Interstitial lung disease (ILD) is an uncommon but clinically important manifestation of systemic lupus erythematosus (SLE).
Mislav Radić, Petra Šimac Prižmić, Tina Bečić, Hana Đogaš, Josipa Radić, Damir Fabijanić, Andrea Gelemanović, Dijana Perković   +7 more
doaj   +1 more source

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. [PDF]

, 2012
BACKGROUND: More than half of patients with multiple sclerosis have progressive disease characterised by accumulating disability. The absence of treatments for progressive multiple sclerosis represents a major unmet clinical need.
Kolappan, Madhan, Thompson, Alan J, Luan, Shi-Lu, Altmann, Daniel R, Crawley, Charles, Compston, Alastair, Patani, Rickie, Scott, Michael A, Du, Ming-Qing, Miller, David H, Michell, Andrew W, Chandran, Siddharthan, Connick, Peter, Webber, Daniel J   +13 more
core   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Discordance Between Patient and Physician Global Assessments in Early Systemic Sclerosis. [PDF]

Arthritis Care Res (Hoboken)
Objective This study aims to identify factors associated with patient global assessment (PtGA) and physician global assessment (PhGA) and discordance between them in systemic sclerosis (SSc). Methods Data from adults with early SSc (<5 years) from the Collaborative National Quality and Efficacy Registry were included.
Romich E, Ogdie A, Stephens Shields A, Merkel PA, Assassi S, Bernstein EJ, Bujor A, Castelino FV, Chung L, Evnin LB, Frech TM, Gordon JK, Griffith M, Hant FN, Harding ML, Hummers LK, Khanna D, Lakin KS, Lebiedz-Odrobina DJ, Luo Y, Makol A, Mayes MD, McMahan ZH, Molitor J, Moore DF, Paik J, Richardson C, Skaug B, Shah AA, Shah A, Steen V, VanBuren JM, Volkmann ER, Zahn C, Sandorfi N, CONQUER Investigators.   +35 more
europepmc   +2 more sources