Results 81 to 90 of about 2,931,663 (352)

B cell abnormalities and autoantibody production in systemic sclerosis [PDF]

, 2006
全身性強皮症（systemic sclerosis ; SSc）では自己抗体の病原性は不明である．CD19はB細胞抗原受容体からのシグナルを増強させ，CD19の過剰発現によって自己抗体産生が誘導される．SSc由来B細胞上ではCD19の発現量は20%増加していた．さらに，SScの動物モデルであるtight-skin (TSK）マウス由来B細胞では，CD19を介するシグナルの増強が認められた．TSKマウスではCD19を欠損させると自己抗体の産生が抑制され，皮膚硬化も減弱し，さらにB細胞からのIL ...
佐藤, 伸一
core   +1 more source

Evaluation of cutaneous microcirculation in systemic sclerosis. An update

, 2023
The impairment of the microcirculation is a crucial aspect of systemic sclerosis which manifests as a plethora of vascular abnormalities. This review examines the methods used in the evaluation of the changes to the microcirculation.
Katarzyna Pawlik, Anna Bohdziewicz, Joanna Czuwara, Małgorzata Olszewska, Jefte Prado, Lidia Rudnicka, Magdalena Maciejewska   +6 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Multiple sclerosis associated with systemic sclerosis

Rheumatology International, 2006
Multiple sclerosis (MS) has been increasingly reported in association with other autoimmune diseases not primary affected the nervous system. The coexistence of MS and systemic sclerosis (SSc) has been rarely described. We report here the case of a 46-year-old female patient with longstanding MS since the age of 26, who developed SSc 12 years later ...
Pelidou, S. H., Tsifetaki, N., Giannopoulos, S., Deretzi, G., Voulgari, P., Kyritsis, A.   +5 more
openaire   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Myocardial Involvement in a Patient with Systemic Sclerosis

Journal of Clinical Rheumatology and Immunology
Myocarditis is an uncommon presentation in systemic sclerosis. We report the case of a patient who developed myocarditis on the initial diagnosis of systemic sclerosis and was successfully managed with optimal medical treatment, including ...
Chris Ching Lam Cheung, Wan Man Choi
doaj   +1 more source

The identification and management of interstitial lung disease in systemic sclerosis: evidence-based European consensus statements.

The Lancet Rheumatology, 2020
BACKGROUND Systemic sclerosis-associated interstitial lung disease (ILD) carries a high mortality risk; expert guidance is required to aid early recognition and treatment.
A. Hoffmann-Vold, T. Maher, E. Philpot, A. Ashrafzadeh, Rafic Barake, S. Barsotti, C. Bruni, P. Carducci, P. Carreira, I. Castellví, F. del Galdo, J. Distler, I. Foeldvari, P. Fraticelli, P. George, B. Griffiths, Alfredo Guillen-Del Castillo, A. Hamid, R. Horváth, M. Hughes, M. Kreuter, F. Moazedi-Fuerst, Jacek Olas, S. Paul, C. Rotondo, M. Rubio-Rivas, A. Seferian, M. Tomčík, Y. Uzunhan, U. Walker, Ewa Więsik-Szewczyk, O. Distler   +31 more
semanticscholar   +1 more source

Esophageal transit scintigraphy in systemic sclerosis

, 2016
Systemic sclerosis is a rare connective tissue disease, distinctive features of which are fibrosis and microangiopathy. The esophagus is one of the most commonly involved internal organs. Most patients experience dysphagia, difficulties in swallowing and
Marzena Olesińska, Marek Chojnowski, Małgorzata Kobylecka   +2 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Renal Involvement in Systemic Sclerosis: An Update

Kidney & Blood Pressure Research, 2020
Background: Systemic sclerosis is an immune-mediated rheumatic disease characterized by vascular abnormalities, tissue fibrosis and autoimmune phenomena.
Magdalena Chrabaszcz, Jolanta Małyszko, Mariusz Sikora, Rosanna Alda-Malicka, Anna Stochmal, Joanna Matuszkiewicz-Rowinska, Lidia Rudnicka   +6 more
doaj   +1 more source