Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation
Advanced Science, EarlyView.This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang +6 more
wiley +1 more source
Diffuse Systemic Sclerosis Presenting as Infarction of Colon [PDF]
, 1960 David Edwards +3 more
openalex +1 more source
Gastrointestinal Manifestations of Systemic Sclerosis
Rheumatology, 2018 Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibroproliferative alterations of the microvasculature leading to fibrosis and loss of function of the skin and internal organs.
Isabel M. McFarlane +13 more
semanticscholar +1 more source
Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells
Advanced Science, EarlyView.Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng +14 more
wiley +1 more source
Leukocyte migration inhibition in progressive systemic sclerosis [PDF]
, 1974 Pamela Hughes, Shirley Holt, N.R. Rowell
openalex +1 more source
Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis
Science Translational Medicine, 2018 Platelet microparticles from patients with systemic sclerosis prompt endothelial cell activation, neutrophil recruitment, and lung fibrosis. Platelets nurture neutrophil damage Systemic sclerosis, or scleroderma, is a complicated inflammatory fibrotic ...
N. Maugeri +12 more
semanticscholar +1 more source
Wearable Bioelectronics for Home‐Based Monitoring and Treatment of Muscle Atrophy
Advanced Science, EarlyView.As an inevitable disease, muscle atrophy has received more attention. Because the factors that induce this disease are diverse, achieving a complete cure is still impossible. Wearable bioelectronics provides a more comfortable, low‐cost, and efficient way of home care for the monitoring and treatment of muscle atrophy. Therefore, this review summarizes
Shuai Zhang +4 more
wiley +1 more source
Some Immunologic Considerations in Focal Scleroderma and Progressive Systemic Sclerosis in Children [PDF]
, 1974 Virgil Hanson +4 more
openalex +1 more source
Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury
Advanced Science, EarlyView.Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley +1 more source
LP-012 Patients with systemic lupus erythematosus and hyperproduction of antibodies to anti-U1RNP
Lupus Science and Medicine, 2023 Oxana Desinova +6 more
doaj +1 more source