Results 51 to 60 of about 584,083 (295)

The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells [PDF]

, 2012
This article is available open access under a Creative Commons license (http://creativecommons.org/licenses/by-nc-nd/3.0/). Copyright @ 2012 Elsevier Inc.Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology. However,
Miao, T, Bhullar, P, Ghaffari, Emma, Liu, Mengya, Liu, M, Wang, Ping, Miao, Tizong, Li, Suling, Wang, P, Sebastian, M, Ghaffari, E, Sebastian, Meera, Symonds, Alistair L.J., Li, S, Symonds, ALJ, Bhullar, Punamdip   +15 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Jasmonic acid and salicylic acid modulate systemic reactive oxygen species signaling during stress response [PDF]

, 2022
Plants can send long-distance cell-to-cell signals from a single tissue subjected to stress to the entire plant. This ability is termed “systemic signaling” and is essential for plant acclimation to stress and/or defense against pathogens.
Fichman, Yosef, Ron Mittler, Myers, Ronald, Sara I Zandalinas, Yosef Fichman, I Zandalinas, Sara, Ronald J Myers, Mittler, Ron   +7 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Systemic signaling in plant gas exchange [PDF]

, 2023
As plants are sessile organisms, the ability to adjust and withstand changing environmental conditions is essential for their survival. Systemic long-distance signaling is known to have an important part in plant responses to abiotic and biotic stresses.
Ehonen, Sanna
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Redox regulation of the NPR1-TGA1 system of Arabidopsis thaliana by nitric oxide [PDF]

, 2010
The role of reactive oxygen and nitrogen species in local and systemic defense reactions is well documented. NPR1 and TGA1 are key redox-controlled regulators of systemic acquired resistance in plants. NPR1 monomers interact with the reduced form of TGA1,
Bernd Müller, Leister, Dario, Jörg Durner, Leister, D., Durner, J., Durner, Jörg, Christian Lindermayr, Lindermayr, C., Sell, S., Lindermayr, Christian, Dario Leister, Sell, Simone, Müller, B., Müller, Bernd, Simone Sell   +14 more
core   +1 more source

Plant elicitor peptide 1 fortifies root cell walls and triggers a systemic root-to-shoot immune signaling in Arabidopsis

Plant Signaling & Behavior, 2022
Plant immunity is initiated by cell surface-localized receptors upon perception of pathogen-derived microbe or pathogen-associated molecular patterns (MAMPs/PAMPs), damage/danger-associated molecular patterns (DAMPs), and phytocytokines.
Jie Zhang, Yuxi Li, Qixin Bao, Hongbo Wang, Shuguo Hou   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Information transfer in signaling pathways : a study using coupled simulated and experimental data [PDF]

, 2008
Background: The topology of signaling cascades has been studied in quite some detail. However, how information is processed exactly is still relatively unknown.
Kummer, U. (Ursula), Green, Anne K., Green, A. K., Kummer, U., Pahle, J., Pahle, Jürgen, Dixon, C. Jane, Dixon, C. J.   +7 more
core   +1 more source