Results 81 to 90 of about 584,083 (295)

Purinergic signaling in infection and autoimmune disease

Biomedical Journal, 2016
Purinergic signaling plays a key role in inflammatory processes and modulates immune responses against a variety of bacterial and eukaryotic parasites.
Luiz Eduardo Baggio Savio, Robson Coutinho-Silva   +1 more
doaj   +1 more source

Cauliflower mosaic virus protein P6 inhibits signaling responses to salicylic acid and regulates innate immunity [PDF]

, 2012
Cauliflower mosaic virus (CaMV) encodes a multifunctional protein P6 that is required for translation of the 35S RNA and also acts as a suppressor of RNA silencing.
Loake, G.J., Byung-Wook Yun, Byung-Wook Yun (127536), Geri, Chiara, Chiara Geri, Gary J. Loake (127540), Milner, J.J., Laird, J., Ari Sadanandom, Yun, B.W., Craig Carr (127532), Janet Laird, Craig Carr, Milner, Joel J., Geri, C., Tada, Y., Joel J. Milner (127553), Carr, Craig, Andrew J Love, Sadanandom, Ari, Janet Laird (127528), Yun, Byung-Wook, Yasuomi Tada, Love, A.J., Yun, B.-W., Gary J Loake, Laird, Janet, Chiara Geri (127524), Yasuomi Tada (127544), Ari Sadanandom (127549), Carr, C., Love, Andrew J., Sadanandom, A., Andrew J. Love (104985), Loake, Gary J., Joel J Milner, Tada, Yasuomi   +36 more
core   +1 more source

N-hydroxypipecolic acid triggers systemic acquired resistance through extracellular NAD(P)

Nature Communications, 2023
Systemic acquired resistance (SAR) is a long-lasting broad-spectrum plant defense mechanism induced in distal systemic tissues by mobile signals generated at the primary infection site.
Qi Li, Mingxi Zhou, Shweta Chhajed, Fahong Yu, Sixue Chen, Yanping Zhang, Zhonglin Mou   +6 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity [PDF]

, 2011
The protein ABIN1 possesses a polyubiquitin-binding domain homologous to that present in nuclear factor kappa B (NF-kappa B) essential modulator (NEMO), a component of the inhibitor of NF-kappa B (I kappa B) kinase (IKK) complex.
Ordureau, Alban, David W. Powell, Rachel Toth, Venigalla, R.K.C., Toth, Rachel, Sambit K. Nanda, J. Simon C. Arthur, Toth, R., Powell, D.W., Venigalla, Ram K. C., Nanda, S.K., C. Arthur, J.S., Janet C. Patterson-Kane, Nanda, Sambit K., Cohen, P., Philip Cohen, Cohen, Philip; id_orcid, Ordureau, A., Arthur, J. Simon C.; id_orcid, Ram K.C. Venigalla, Patterson-Kane, J.C., Alban Ordureau, Patterson-Kane, Janet C., Powell, David W.   +23 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

An endogenous danger detection system in "Arabidopsis thaliana": the AtPep peptides and their receptors

, 2014
Plants use a plethora of sophisticated detection systems to recognize a variety of attackers and to subsequently initiate defense responses. A well-known paradigm in this context is the perception of microbe-associated molecular patterns (MAMPs) by ...
Klauser, Dominik Roman
core   +1 more source

Fever-like temperature modification differentially affects in vitro signaling of bradykinin B-1 and B-2 receptors [PDF]

, 2011
The bradykinin (BK) B-2 and B-1 receptors (B2R, B1R) belong to the rhodopsin-like G protein-coupled receptors (GPCRs) and are involved in (patho)physiological processes such as blood pressure regulation or inflammation.
Dinkel, Klaus, Faussner, Alexander, Marianne Jochum, Jasmin Leschner, Alexander Faussner, Jochum, Marianne, Leschner, Jasmin, Larisa Ring, Ring, Larisa, Jens Feierler, Feierler, Jens, Klaus Dinkel   +11 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Interplay Between ROS and Hormones in Plant Defense Against Pathogens

Plants
Reactive oxygen species (ROS) are toxic by-products of aerobic cellular metabolism. However, ROS conduct multiple functions, and specific ROS sources can have beneficial or detrimental effects on plant health. This review explores the complex dynamics of
Mostafa Haghpanah, Amin Namdari, Mostafa Koozehgar Kaleji, Azam Nikbakht-dehkordi, Ahmad Arzani, Fabrizio Araniti   +5 more
doaj   +1 more source