Results 91 to 100 of about 4,055,022 (317)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Impact of Control System Structure and Performance of Inventory Goods Flow System with Long-Variable Delay

Elektronika ir Elektrotechnika, 2018
In this paper, we use a mathematical model of a inventory system with time-varying delivery delay and three control systems  in order to compare their properties for the goods flow optimization problem in the inventory systems.
Ewelina Cholodowicz, Przemyslaw Orlowski
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Influence of Enzymatic Acylation on the Stability and Antioxidant Properties of Cyanidin-3-O-Glucoside in Both Aqueous and Lipid Systems

Molecules
Cyanidin-3-O-glucoside (C3G) was used as a substrate for enzymatic acylation, and different compounds (methyl n-octanoate and methyl salicylate) were selected as acyl donors.
Ziwei Ye, Mingyun Liu, Jingmei Lyu, Han Rong, Lujing Gan   +4 more
doaj   +1 more source

Analysis of Healthcare Systems by Using Systemic Approach

Complexity, 2019
National healthcare systems in all countries do not act effectively. Therefore, especially strategies for introducing organizational innovation to public organization should be considered. The problem is how to organize the research in this field. One of
Andrzej Bielecki, Sylwia Nieszporska
doaj   +1 more source

Towards Realizability Checking of Contracts using Theories

, 2015
Virtual integration techniques focus on building architectural models of systems that can be analyzed early in the design cycle to try to lower cost, reduce risk, and improve quality of complex embedded systems.
Backes, John, Cofer, Darren, Gacek, Andrew, Katis, Andreas, Whalen, Michael W.   +4 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Quality-aware model-driven service engineering [PDF]

, 2008
Service engineering and service-oriented architecture as an integration and platform technology is a recent approach to software systems integration.
Barrett, Ronan, Boskovic, Marko, Hasselbring, Wilhelm, Pahl, Claus   +3 more
core  

Anomalous Normal-State Properties of High-T$_c$ Superconductors -- Intrinsic Properties of Strongly Correlated Electron Systems?

, 1995
A systematic study of optical and transport properties of the Hubbard model, based on Metzner and Vollhardt's dynamical mean-field approximation, is reviewed.
Anderson P.W., Dessau D., Grewe N., Itzykson C., J.K. Freericks, Janiˇs V., Jarrell M., Keiter H., Loidl A., M. Jarrell, Madelung O., Migdal A.B., Pennington C.H., Quitmann C., Schweitzer H., Th. Pruschke, Vollhardt D.   +16 more
core   +2 more sources