Results 101 to 110 of about 12,538,458 (271)

Tools for efficient analysis of concurrent software systems [PDF]

, 1985
The ever increasing use of distributed computing as a method of providing added computing power and reliability has sparked interest in methods to model and analyze concurrent hardware/ software systems.
Hirschberg, Daniel S., Razouk, Rami R.
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Social Intelligence Mining: Transforming Land Management with Data and Deep Learning

Land
The integration of social intelligence mining with Large Language Models (LLMs) and unstructured social data can enhance land management by incorporating human behavior, social trends, and collective decision-making.
Mohammad Reza Yeganegi, Hossein Hassani, Nadejda Komendantova   +2 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Performance Analysis of Publish/Subscribe Systems

, 2007
The Desktop Grid offers solutions to overcome several challenges and to answer increasingly needs of scientific computing. Its technology consists mainly in exploiting resources, geographically dispersed, to treat complex applications needing big power ...
Abbes, Heithem, Cérin, Christophe, Dubacq, Jean-Christophe, Jemni, Mohamed   +3 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Global exposure and vulnerability to multi-sector development and climate change hotspots

Environmental Research Letters, 2018
Understanding the interplay between multiple climate change risks and socioeconomic development is increasingly required to inform effective actions to manage these risks and pursue sustainable development.
Edward Byers, Matthew Gidden, David Leclère, Juraj Balkovic, Peter Burek, Kristie Ebi, Peter Greve, David Grey, Petr Havlik, Astrid Hillers, Nils Johnson, Taher Kahil, Volker Krey, Simon Langan, Nebjosa Nakicenovic, Robert Novak, Michael Obersteiner, Shonali Pachauri, Amanda Palazzo, Simon Parkinson, Narasimha D Rao, Joeri Rogelj, Yusuke Satoh, Yoshihide Wada, Barbara Willaarts, Keywan Riahi   +25 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Radar altimetry systems cost analysis [PDF]

This report discusses the application and cost of two types of altimeter systems (spaceborne (satellite and shuttle) and airborne) to twelve user requirements.
Denman, W. F., Escoe, D., Heuring, F. T.
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source