Results 171 to 180 of about 13,108,811 (339)

Editorial: Virtual patients and digital twins in the systems analysis of drug discovery and development. [PDF]

Front Syst Biol, 2023
Zhao C, He H, Ma H.
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The breast cancer risk assessment pathway in England: a systems analysis of current challenges and ways to improve. [PDF]

Br J Cancer
Valasaki M, Taylor LC, Woof VG, Howell SJ, Tischkowitz M, Antoniou AC, Archer S, French DP, Usher-Smith JA.   +8 more
europepmc   +1 more source

Portal Venous Remodeling Determines the Pattern of Cirrhosis Decompensation: A Systems Analysis. [PDF]

Clin Transl Gastroenterol, 2023
Mazumder NR, Jezek F, Tapper EB, Beard DA.   +3 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Systems analysis of leaf anatomy and transcriptome using unsupervised machine learning provides insight on photosynthesis development and evolution in non-model grasses. [PDF]

Plant Direct
Prochetto S, Stegmayer G, Studer AJ, Reinheimer R.   +3 more
europepmc   +1 more source

Efficient Feasibility Analysis for Real-Time Systems with EDF Scheduling [PDF]

, 2007
Karsten Albers, Frank Slomka
openalex   +1 more source

Review for "Development of a wind power ramp forecasting system via meteorological pattern analysis"

, 2021

openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Supporting One Health policies to manage antibiotic resistance in Senegal: a systems analysis using group model building. [PDF]

Front Public Health
Sow MM, Ciss M, Diouf ND, Fall AG, Dia NM, Penney T, Bordier M, Clifford Astbury C.   +7 more
europepmc   +1 more source