FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Performance Analysis of Data Augmentation Approaches for Improving Wrist-Based Fall Detection System
SensorsThe aging of society is a global concern nowadays. Falls and fall-related injuries can influence the elderly’s daily living, including physical damage, psychological effects, and financial problems. A reliable fall detection system can trigger an alert immediately when a fall event happens to reduce the adverse effects of falls.
Yu-Chen Tu +3 more
openaire +3 more sources
Knowledge representation within information systems in manufacturing environments [PDF]
, 2004 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Representing knowledge as information content alone is insufficient in providing us with an understanding of the world around us.
Sharif, Amir M
core +3 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Providing "a beam of light to see the gaps": determinants of implementation of the Systems Analysis and Improvement Approach applied to the pediatric and adolescent HIV cascade in Kenya. [PDF]
Implement Sci Commun, 2022 Beima-Sofie K +16 more
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
EconomiesEnergy innovation plays an important role in the transition to a zero-carbon economy. Governments in IEA member countries are investing in the R&D, demonstration, and deployment of new energy technologies as part of their energy and climate policies.
Svetlana V. Ratner +2 more
openaire +3 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Results of a cluster randomized trial testing the systems analysis and improvement approach to increase HIV testing in family planning clinics. [PDF]
AIDS, 2022 Eastment MC +9 more
europepmc +1 more source