Results 181 to 190 of about 2,989,026 (346)

The Need for a Systems Biology Approach in Cancer Explained. [PDF]

Int J Mol Sci
Zhu H, Zhang X, Nazemalhosseini-Mojarad E, Roelands J, de Muynck LDAN, Ravensbergen CJ, Hoorntje R, Stouten I, Hokland M, Vahrmeijer AL, Tollenaar RAEM, Koster E, Kuppen PJK.   +12 more
europepmc   +1 more source

Systems Biology Profiling of AMD on the Basis of Gene Expression [PDF]

, 2013
Mones Abu‐Asab, José Salazar, Jingsheng Tuo, Chi‐Chao Chan   +3 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Rethinking medical education through systems biology to address complexity. [PDF]

NPJ Syst Biol Appl
David L, Gourraud PA, Lamirault G, Lemarchand P.   +3 more
europepmc   +1 more source

Status and Challenges of Reproducibility in Computational Systems and Synthetic Biology

, 2019
Kiri Choi, Jonathan R. Karr, Herbert M. Sauro   +2 more
openalex   +1 more source

Gene transfer into chicken embryos as an effective system of analysis in developmental biology [PDF]

, 2000
Sadao Yasugi, Harukazu Nakamura
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Mapping physiology: A systems biology approach for the development of alternative methods in toxicology

Bernard Staumont, Luiz Carlos Maia Ladeira, A. Gamba, Harm J. Heusinkveld, Aldert H. Piersma, Ellen Fritsche, Rosalinde Masereeuw, Tamara Vanhaecke, Marc Teunis, T. Luechtefeld, Thomas Härtung, Ramiro Jover, Mathieu Vinken, Liesbet Geris   +13 more
openalex   +1 more source

“Gestaltomics”: Systems Biology Schemes for the Study of Neuropsychiatric Diseases [PDF]

, 2017
Nora A. Gutierrez Najera, Osbaldo Reséndis-Antonio, Humberto Nicolini   +2 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source