Results 181 to 190 of about 1,150,837 (304)

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

SBMLtoOdin and Menelmacar: interactive visualisation of systems biology models for expert and non-expert audiences. [PDF]

Bioinformatics
Lorenz LJ, Andréoletti A, Nguyen TVN, Hermjakob H, FitzJohn RG, Malik Sheriff RS, Lees JA.   +6 more
europepmc   +1 more source

Systems biology: A primer [PDF]

NeuroRX, 2006
Timothy R. Mhyre, Howard J. Federoff
openaire   +3 more sources

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

A systems biology approach to understand temporal evolution of silver nanoparticle toxicity. [PDF]

NPJ Syst Biol Appl
Park SG, Lee E, Kim HY, Yoon TH.
europepmc   +1 more source

Application of the mouse exo utero development system in the study of developmental biology and teratology [PDF]

, 2004
Toshihisa Hatta, Akihiro Matsumoto, Hiroki Otani   +2 more
openalex   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Reconciling multiple connectivity-based systems biology methods for drug repurposing. [PDF]

Brief Bioinform
Gonzalez Gomez C, Rosa-Calatrava M, Fouret J.   +2 more
europepmc   +1 more source

Applications of the Aurora parallel Prolog system to computational molecular biology

, 1993
Ewing Lusk, Shyam Mudambi, Ross Overbeek, Péter Szeredi   +3 more
openalex   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source