Results 161 to 170 of about 12,579,596 (265)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Leveraging latent patterns in the study of living systems

, 2019
Thesis: Ph. D., Massachusetts Institute of Technology, Computational and Systems Biology Program, 2019Cataloged from PDF version of thesis. "June 2019."Includes bibliographical references.The development of high-throughput techniques to observe and ...
Cleary, Brian(Brian Lowman)
core  

Cancer as a System Failure

Cancer Informatics, 2007
Igor Jurisica, Dennis Wigle
doaj  

Systems Biology and Structure-Based In Silico Evaluations of Quercetin-Psychobiotic Interactions for the Management of Depression. [PDF]

Pharmaceuticals (Basel)
Kurl S, Mittal N, Kaur R, Chandrasekaran B, Kaur G.   +4 more
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Epigenetic and post-transcriptional regulation of gene expression in pluripotent stem cells, differentiation and metastasis

, 2014
Thesis: Ph. D., Massachusetts Institute of Technology, Computational and Systems Biology Program, 2014.Cataloged from PDF version of thesis.Includes bibliographical references.Transmission of information from DNA to RNA to protein underlies the core of ...
Cheng, Wu Albert
core  

From molecular networks to the clinic: a systems biology-nanomedicine roadmap for osteoarthritis diagnosis, regeneration, and safety-by-design. [PDF]

Discov Nano
Dortaj H, Asoudeh-Fard A, Alizadeh A, Vaez A, Gholami A.   +4 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Revisiting Ehrlich carcinoma in the era of precision oncology: bridging classical models with modern systems biology. [PDF]

Med Oncol
Manjunath V, Nayak RR, Bhujanga AK, Ramesh AM, Santhekadur PK.   +4 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source