Results 151 to 160 of about 12,579,596 (265)

The principles of systems biology. [PDF]

Exp Physiol
Noble D, Bourret R.
europepmc   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Systems biology in the era of AI: "winter" or "evolution"? [PDF]

Front Syst Biol
Helmy M, Selvarajoo K.
europepmc   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Systems Biology

, 2009
2e edSystems biology focuses on the systematic study of complex interactions in biological systems using high-throughput genome-wide technologies, such as transcriptomics, proteomics, and metabolomics.
Coulier, L., Wopereis, S., Hendriks, H., Jellema, R.H., Radonjić, M., Rubingh, C.   +5 more
core  

The Great Escape: the systems biology of endocrine resistance and lineage plasticity. [PDF]

Endocr Relat Cancer
Dragnev CPC, Fu Z, Huang S, Perry CJ, Kahn A, Dinan MA, Shen Tan W, Leapman M, Braun DA, Warrick J, Beltran H, Mu P.   +11 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Bioinformatics and Systems Biology

BioTechniques, 2009
Lynne Lederman
doaj   +1 more source

Systems biology during 20 years of PLoS Computational Biology. [PDF]

PLoS Comput Biol
Alber M, Birtwistle MR, Finley SD, Mendes P.   +3 more
europepmc   +1 more source