Results 131 to 140 of about 11,342,017 (299)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Systems biology or the biology of systems: routes to reducing hunger [PDF]

New Phytologist, 2008
J E, Sheehy, D, Gunawardana, A B, Ferrer, F, Danila, K G, Tan, P L, Mitchell   +5 more
openaire   +2 more sources

Systems evolutionary biology : biological network evolution theory, stochastic evolutionary game strategies, and applications to systems synthetic biology /

Systems Evolutionary Biology: Biological Network Evolution Theory, Stochastic Evolutionary Game Strategies, and Applications to Systems Synthetic Biology discusses the evolutionary game theory and strategies of nonlinear stochastic biological networks ...
Chen, Bor-Sen,author.
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Editorial: Cancer systems biology

Frontiers in Genetics, 2022
Jesús Espinal-Enríquez, Claudia Rangel-Escareño, Claudia Rangel-Escareño, Frank Emmert-Streib   +3 more
doaj   +1 more source

Aberrant mRNA splicing and impaired hippocampal neurogenesis in Grin2b mutant mice

iScience
Summary: NMDA receptor dysfunction is implicated in the pathophysiology of autism spectrum disorder (ASD). Here, we investigated heterozygous mouse mutants carrying the ASD-linked C456Y mutation of Grin2b, a high-confidence ASD risk gene encoding the ...
Zohreh Farsi, Ally Nicolella, Sean K. Simmons, Wangyong Shin, Muwon Kang, Gina Lee, Min Jee Kwon, Kira S. Brenner, Ines Picard, Nate Shepard, Deeksha Misri, Kira A. Perzel Mandell, Joshua Z. Levin, Eunjoon Kim, Morgan Sheng   +14 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Systems biology approaches for chemical engineering [PDF]

, 2011
Biological systems are becoming of central interest also in fields which go beyond science and medicine scopes, such as chemical engineering. In the last decades, some complex biological systems have been considered for large scale chemicals production ...
Gatto, Fancesco
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